Tinatin I. Brelidze, Ph.D.

Affiliations: 
2003 University of Miami, Coral Gables, FL 
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"Tinatin Brelidze"
Mean distance: 15.12 (cluster 46)
 
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Karl L. Magleby grad student 2003 University of Miami
 (Limits and contributing mechanisms for big single -channel currents in BK channels.)
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Publications

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Carlson AE, Rosenbaum JC, Brelidze TI, et al. (2013) Flavonoid regulation of HCN2 channels. The Journal of Biological Chemistry. 288: 33136-45
Brelidze TI, Gianulis EC, DiMaio F, et al. (2013) Structure of the C-terminal region of an ERG channel and functional implications. Proceedings of the National Academy of Sciences of the United States of America. 110: 11648-53
Carlson AE, Brelidze TI, Zagotta WN. (2013) Flavonoid regulation of EAG1 channels. The Journal of General Physiology. 141: 347-58
Brelidze TI, Carlson AE, Sankaran B, et al. (2012) Structure of the carboxy-terminal region of a KCNH channel. Nature. 481: 530-3
Brelidze TI, Carlson AE, Davies DR, et al. (2010) Identifying regulators for EAG1 channels with a novel electrophysiology and tryptophan fluorescence based screen. Plos One. 5
Brelidze TI, Carlson AE, Zagotta WN. (2009) Absence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methods. The Journal of Biological Chemistry. 284: 27989-97
Zhang Y, Niu X, Brelidze TI, et al. (2006) Ring of negative charge in BK channels facilitates block by intracellular Mg2+ and polyamines through electrostatics. The Journal of General Physiology. 128: 185-202
Brelidze TI, Magleby KL. (2005) Probing the geometry of the inner vestibule of BK channels with sugars. The Journal of General Physiology. 126: 105-21
Brelidze TI, Magleby KL. (2004) Protons block BK channels by competitive inhibition with K+ and contribute to the limits of unitary currents at high voltages. The Journal of General Physiology. 123: 305-19
Brelidze TI, Niu X, Magleby KL. (2003) A ring of eight conserved negatively charged amino acids doubles the conductance of BK channels and prevents inward rectification. Proceedings of the National Academy of Sciences of the United States of America. 100: 9017-22
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