Heather A. O'Malley, Ph.D.

Affiliations: 
2009 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Sodium Channels
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"Heather O'Malley"
Mean distance: 17.55 (cluster 11)
 
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Lori Isom grad student 2009 University of Michigan
 (The role of sodium channel alpha and beta subunits in myelinating glia and demyelinating disorders.)
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Publications

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Yuan Y, Lopez-Santiago L, Denomme N, et al. (2023) ASO restores excitability, GABA signalling and sodium current density in a model of Dravet syndrome. Brain : a Journal of Neurology
Hull JM, O'Malley HA, Chen C, et al. (2020) Excitatory and inhibitory neuron defects in a mouse model of Scn1b-linked EIEE52. Annals of Clinical and Translational Neurology
O'Malley HA, Hull JM, Clawson BC, et al. (2019) deletion in adult mice results in seizures and SUDEP. Annals of Clinical and Translational Neurology. 6: 1121-1126
Yuan Y, O'Malley HA, Smaldino MA, et al. (2019) Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome. Scientific Reports. 9: 6210
Lopez-Santiago LF, Yuan Y, Wagnon JL, et al. (2017) Neuronal hyperexcitability in a mouse model of SCN8A epileptic encephalopathy. Proceedings of the National Academy of Sciences of the United States of America
Kruger LC, O'Malley HA, Hull JM, et al. (2016) β1-C121W Is Down But Not Out: Epilepsy-Associated Scn1b-C121W Results in a Deleterious Gain-of-Function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 6213-24
Signore S, Sorrentino A, Borghetti G, et al. (2015) Late Na(+) current and protracted electrical recovery are critical determinants of the aging myopathy. Nature Communications. 6: 8803
Lin X, O'Malley H, Chen C, et al. (2015) Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts. The Journal of Physiology. 593: 1389-407
O'Malley HA, Isom LL. (2015) Sodium channel β subunits: emerging targets in channelopathies. Annual Review of Physiology. 77: 481-504
Liu Y, Lopez-Santiago LF, Yuan Y, et al. (2013) Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism. Annals of Neurology. 74: 128-39
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