Heather A. O'Malley, Ph.D.
Affiliations: | 2009 | University of Michigan, Ann Arbor, Ann Arbor, MI |
Area:
Sodium ChannelsGoogle:
"Heather O'Malley"Mean distance: 17.55 (cluster 11) | S | N | B | C | P |
Parents
Sign in to add mentorLori Isom | grad student | 2009 | University of Michigan | |
(The role of sodium channel alpha and beta subunits in myelinating glia and demyelinating disorders.) |
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Publications
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Yuan Y, Lopez-Santiago L, Denomme N, et al. (2023) ASO restores excitability, GABA signalling and sodium current density in a model of Dravet syndrome. Brain : a Journal of Neurology |
Hull JM, O'Malley HA, Chen C, et al. (2020) Excitatory and inhibitory neuron defects in a mouse model of Scn1b-linked EIEE52. Annals of Clinical and Translational Neurology |
O'Malley HA, Hull JM, Clawson BC, et al. (2019) deletion in adult mice results in seizures and SUDEP. Annals of Clinical and Translational Neurology. 6: 1121-1126 |
Yuan Y, O'Malley HA, Smaldino MA, et al. (2019) Delayed maturation of GABAergic signaling in the Scn1a and Scn1b mouse models of Dravet Syndrome. Scientific Reports. 9: 6210 |
Lopez-Santiago LF, Yuan Y, Wagnon JL, et al. (2017) Neuronal hyperexcitability in a mouse model of SCN8A epileptic encephalopathy. Proceedings of the National Academy of Sciences of the United States of America |
Kruger LC, O'Malley HA, Hull JM, et al. (2016) β1-C121W Is Down But Not Out: Epilepsy-Associated Scn1b-C121W Results in a Deleterious Gain-of-Function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 6213-24 |
Signore S, Sorrentino A, Borghetti G, et al. (2015) Late Na(+) current and protracted electrical recovery are critical determinants of the aging myopathy. Nature Communications. 6: 8803 |
Lin X, O'Malley H, Chen C, et al. (2015) Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts. The Journal of Physiology. 593: 1389-407 |
O'Malley HA, Isom LL. (2015) Sodium channel β subunits: emerging targets in channelopathies. Annual Review of Physiology. 77: 481-504 |
Liu Y, Lopez-Santiago LF, Yuan Y, et al. (2013) Dravet syndrome patient-derived neurons suggest a novel epilepsy mechanism. Annals of Neurology. 74: 128-39 |