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Brian Finan, Ph.D.

Affiliations: 
2011 Biochemistry Indiana University, Bloomington, Bloomington, IN, United States 
Area:
endocrinology, specifically diabetes
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Richard DiMarchi grad student 2011 Indiana University
 (Peptide targeting of nuclear hormone action leads to enhanced efficacy and safety in the treatment of the metabolic syndrome.)

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Publications

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Liskiewicz A, Khalil A, Liskiewicz D, et al. (2023) Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice. Nature Metabolism
Sachs S, Götz A, Finan B, et al. (2023) GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease. Cardiovascular Diabetology. 22: 217
Campbell JE, Müller TD, Finan B, et al. (2023) GIPR/GLP-1R dual agonist therapies for diabetes and weight loss-chemistry, physiology, and clinical applications. Cell Metabolism
Wewer Albrechtsen NJ, Holst JJ, Cherrington AD, et al. (2023) 100 years of glucagon and 100 more. Diabetologia. 66: 1378-1394
El K, Douros JD, Willard FS, et al. (2023) The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets. Nature Metabolism
Yang B, Gelfanov VM, El K, et al. (2022) Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems. Molecular Metabolism. 101638
Sekar R, Motzler K, Kwon Y, et al. (2022) Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes. Cell Metabolism
Quarta C, Stemmer K, Novikoff A, et al. (2022) GLP-1-mediated delivery of tesaglitazar improves obesity and glucose metabolism in male mice. Nature Metabolism. 4: 1071-1083
Kim T, Nason S, Antipenko J, et al. (2022) Hepatic TORC2 Signaling Facilitates Acute Glucagon-Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice. Diabetes
Knerr PJ, Mowery SA, Douros JD, et al. (2022) Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice. Molecular Metabolism. 101533
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