Alison C. Donnelly, Ph.D.
Affiliations: | 2011 | Medicinal Chemistry | University of Kansas, Lawrence, KS, United States |
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"Alison Donnelly"Mean distance: 9.16 | S | N | B | C | P |
Parents
Sign in to add mentor| Brian Blagg | grad student | 2011 | University of Kansas | |
| (Design, Synthesis and Evaluation of Non-Canonical Hsp90 Modulators.) | ||||
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Publications
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| Iwai A, Bourboulia D, Mollapour M, et al. (2012) Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells. Cell Cycle (Georgetown, Tex.). 11: 3649-55 |
| Eskew JD, Sadikot T, Morales P, et al. (2011) Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells. Bmc Cancer. 11: 468 |
| Samadi AK, Zhang X, Mukerji R, et al. (2011) A novel C-terminal HSP90 inhibitor KU135 induces apoptosis and cell cycle arrest in melanoma cells. Cancer Letters. 312: 158-67 |
| Zhao H, Donnelly AC, Kusuma BR, et al. (2011) Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents. Journal of Medicinal Chemistry. 54: 3839-53 |
| Matts RL, Brandt GE, Lu Y, et al. (2011) A systematic protocol for the characterization of Hsp90 modulators. Bioorganic & Medicinal Chemistry. 19: 684-92 |
| Mollapour M, Tsutsumi S, Donnelly AC, et al. (2010) Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function. Molecular Cell. 37: 333-43 |
| Matthews SB, Vielhauer GA, Manthe CA, et al. (2010) Characterization of a novel novobiocin analogue as a putative C-terminal inhibitor of heat shock protein 90 in prostate cancer cells. The Prostate. 70: 27-36 |
| Donnelly AC, Zhao H, Reddy Kusuma B, et al. (2010) Cytotoxic sugar analogues of an optimized novobiocin scaffold Medchemcomm. 1: 165-170 |
| Shelton SN, Shawgo ME, Matthews SB, et al. (2009) KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells. Molecular Pharmacology. 76: 1314-22 |
| Donnelly A, Blagg BS. (2008) Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket. Current Medicinal Chemistry. 15: 2702-17 |