James F. Otto, Ph.D.

2006 University of Utah, Salt Lake City, UT 
epilepsy, anticonvulsant drug development, electrophysiology
"James Otto"
Mean distance: 16.44 (cluster 11)


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Karen S. Wilcox grad student 2006 University of Utah
 (Examining the role of the M-type potassium current in epilepsy using mice that carry KCNQ2 and KCNQ3 gene alterations.)
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Otto JF, Singh NA, Dahle EJ, et al. (2009) Electroconvulsive seizure thresholds and kindling acquisition rates are altered in mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions. Epilepsia. 50: 1752-9
Singh NA, Otto JF, Leppert MF, et al. (2009) Mouse models of benign familial neonatal convulsions (BFNC): Mutations in KCNQ (Kv7) genes Neuromethods. 40: 107-120
Singh NA, Otto JF, Dahle EJ, et al. (2008) Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization. The Journal of Physiology. 586: 3405-23
Simeone TA, Otto JF, Wilcox KS, et al. (2006) Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes. European Journal of Pharmacology. 552: 31-5
Otto JF, Yang Y, Frankel WN, et al. (2006) A spontaneous mutation involving Kcnq2 (Kv7.2) reduces M-current density and spike frequency adaptation in mouse CA1 neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 2053-9
Bamber BA, Richmond JE, Otto JF, et al. (2005) The composition of the GABA receptor at the Caenorhabditis elegans neuromuscular junction. British Journal of Pharmacology. 144: 502-9
Otto JF, Yang Y, Frankel WN, et al. (2004) Mice carrying the szt1 mutation exhibit increased seizure susceptibility and altered sensitivity to compounds acting at the m-channel. Epilepsia. 45: 1009-16
Yang Y, Beyer BJ, Otto JF, et al. (2003) Spontaneous deletion of epilepsy gene orthologs in a mutant mouse with a low electroconvulsive threshold. Human Molecular Genetics. 12: 975-84
Otto JF, Kimball MM, Wilcox KS. (2002) Effects of the anticonvulsant retigabine on cultured cortical neurons: changes in electroresponsive properties and synaptic transmission. Molecular Pharmacology. 61: 921-7
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