Emmanuel J. Botzolakis, MD PhD

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Ion Channels, Kinetic Modeling, Receptor Assembly, Receptor Trafficking
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"Emmanuel Botzolakis"
Mean distance: 16.05 (cluster 46)
 
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Publications

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Botzolakis EJ, Gurba KN, Lagrange AH, et al. (2016) Comparison of GABA-A Receptor αβγ and αβδ Expression Using Flow Cytometry and Electrophysiology: Evidence for Alternate Subunit Stoichiometries and Arrangements. The Journal of Biological Chemistry
Todd E, Gurba KN, Botzolakis EJ, et al. (2014) GABAA receptor biogenesis is impaired by the γ2 subunit febrile seizure-associated mutation, GABRG2(R177G). Neurobiology of Disease. 69: 215-24
Botzolakis EJ, Zhao J, Gurba KN, et al. (2011) The effect of HSP-causing mutations in SPG3A and NIPA1 on the assembly, trafficking, and interaction between atlastin-1 and NIPA1. Molecular and Cellular Neurosciences. 46: 122-35
Leu RM, Beyderman L, Botzolakis EJ, et al. (2011) Relation of melatonin to sleep architecture in children with autism. Journal of Autism and Developmental Disorders. 41: 427-33
Ding L, Feng HJ, Macdonald RL, et al. (2010) GABA(A) receptor alpha1 subunit mutation A322D associated with autosomal dominant juvenile myoclonic epilepsy reduces the expression and alters the composition of wild type GABA(A) receptors. The Journal of Biological Chemistry. 285: 26390-405
Bianchi MT, Botzolakis EJ. (2010) Targeting ligand-gated ion channels in neurology and psychiatry: is pharmacological promiscuity an obstacle or an opportunity? Bmc Pharmacology. 10: 3
Macdonald RL, Botzolakis EJ. (2010) GABAA receptor channels Physiology and Pathology of Chloride Transporters and Channels in the Nervous System. 257-282
Bianchi MT, Botzolakis EJ, Lagrange AH, et al. (2009) Benzodiazepine modulation of GABA(A) receptor opening frequency depends on activation context: a patch clamp and simulation study. Epilepsy Research. 85: 212-20
Botzolakis EJ, Maheshwari A, Feng HJ, et al. (2009) Achieving synaptically relevant pulses of neurotransmitter using PDMS microfluidics. Journal of Neuroscience Methods. 177: 294-302
Feng HJ, Botzolakis EJ, Macdonald RL. (2009) Context-dependent modulation of alphabetagamma and alphabetadelta GABA A receptors by penicillin: implications for phasic and tonic inhibition. Neuropharmacology. 56: 161-73
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