Jeffrey R. Holt
Affiliations: | Harvard University, Cambridge, MA, United States |
Area:
sensory hair cellsWebsite:
https://sites.google.com/site/holtgeleoclab/peopleGoogle:
"Jeffrey Holt"Mean distance: 14 (cluster 6) | S | N | B | C | P |
Parents
Sign in to add mentor| Ruth Anne Eatock | grad student | 1991-1995 | Rochester |
| David P. Corey | post-doc | 1995-2001 | Harvard Medical School/ MGH |
Children
Sign in to add trainee| Michaela Levin | grad student | UVA | |
| Jessica R. Risner | grad student | 2002-2008 | UVA |
| Eric A. Stauffer | grad student | 2003-2008 | UVA |
| Geoffrey C. Horwitz | grad student | 2006-2012 | UVA |
| Ye-Hyun Kim | grad student | 2008-2014 | University of Virginia, Harvard |
| Charles Askew | grad student | 2008-2015 | University of Virginia, Harvard |
| Xiao Ping Liu | post-doc | Harvard |
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Publications
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| Zheng W, Rawson S, Shen Z, et al. (2023) TMEM63 proteins function as monomeric high-threshold mechanosensitive ion channels. Neuron |
| Giese APJ, Weng WH, Kindt KS, et al. (2023) Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels. Biorxiv : the Preprint Server For Biology |
| Mathiesen BK, Miyakoshi LM, Cederroth CR, et al. (2023) Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice. Science Translational Medicine. 15: eabq3916 |
| Marcovich I, Baer NK, Shubina-Oleinik O, et al. (2022) Optimized AAV Vectors for TMC1 Gene Therapy in a Humanized Mouse Model of DFNB7/11. Biomolecules. 12 |
| van Beelen ESA, van der Valk WH, Verhagen TO, et al. (2022) Efficient Viral Transduction in Fetal and Adult Human Inner Ear Explants with AAV9-PHP.B Vectors. Biomolecules. 12 |
| Lee J, Kosuke Kawai K, Holt JR, et al. (2021) Sensory transduction is required for normal development and maturation ofcochlear inner hair cell synapses. Elife. 10 |
| Taiber S, Cohen R, Yizhar-Barnea O, et al. (2020) Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness. Embo Molecular Medicine. e13259 |
| Zheng W, Holt JR. (2020) The Mechanosensory Transduction Machinery in Inner Ear Hair Cells. Annual Review of Biophysics |
| Wu J, Solanes P, Nist-Lund C, et al. (2020) Single and dual vector gene therapy with AAV9-PHP.B rescues hearing in Tmc1 mutant mice. Molecular Therapy : the Journal of the American Society of Gene Therapy |
| Holt JR, Raphael Y. (2020) Introduction to the Hearing Research special issue on inner ear gene therapy. Hearing Research. 108010 |