Ki-Jun Yoon

Affiliations: 
1999-2003 Life Science (B.S.) Pohang Univerisity of Science and Technology (POSTECH), Pohang, Gyeongsangbuk-do, South Korea 
 2003-2008 Life Science (Ph.D) Pohang Univerisity of Science and Technology (POSTECH), Pohang, Gyeongsangbuk-do, South Korea 
 2008-2009 Biological Sciences Seoul National University, Seoul, South Korea 
 2010-2017 Neurology/ NeuroICE Johns Hopkins University School of Medicine, Baltimore, MD, United States 
 2017- Neuroscience University of Pennsylvania Perelman School of Medicine 
Area:
Neural Stem Cell Biology
Google:
"Ki-Jun Yoon"
Bio:

Proper development of the nervous system is critical for its function, and deficits in neural development have been implicated in many brain disorders, such as microcephaly, autistm spectrum disorders, and schizophrenia. Neural stem cells are the origins of all types of cells in the nervous system and their behaviors are tightly controlled by intrinsic developmental programs in specific species. My lifelong question is how neural stem cells are regulated to achieve the precise cell division, cell migration, and cell fate specification during the embryonic brain development. Especially, an important area of my ongoing research is investigating the role of RNA modifications in the neural stem cells, which provide rapid and fine-tuned gene expression post-transcriptionally. In addition, I am also studying the risk factors of neurodevelopmental disorders, such as genetic mutations responsible for schizophrenia risk and Zika virus infection, using both mouse and human iPSC models.

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Publications

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Habela CW, Yoon KJ, Kim N, et al. (2020) Persistent Cyfip1 expression is required to maintain the adult subventricular zone neurogenic niche. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
Zhou Y, Bond AM, Shade JE, et al. (2018) Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool. Cell Stem Cell
Yoon KJ, Ming GL, Song H. (2018) Epitranscriptomes in the Adult Mammalian Brain: Dynamic Changes Regulate Behavior. Neuron. 99: 243-245
Yoon KJ, Vissers C, Ming GL, et al. (2018) Epigenetics and epitranscriptomics in temporal patterning of cortical neural progenitor competence. The Journal of Cell Biology
Yoon KJ, Ming GL, Song H. (2018) Coupling Neurogenesis to Circuit Formation. Cell. 173: 288-290
Song G, Rho HS, Pan J, et al. (2017) Multiplexed biomarker panels discriminate Zika and Dengue virus infection in humans. Molecular & Cellular Proteomics : McP
Yoon KJ, Ringeling FR, Vissers C, et al. (2017) Temporal Control of Mammalian Cortical Neurogenesis by m(6)A Methylation. Cell
Yoon KJ, Song G, Qian X, et al. (2017) Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins. Cell Stem Cell
Zhang F, Hammack C, Ogden SC, et al. (2016) Molecular signatures associated with ZIKV exposure in human cortical neural progenitors. Nucleic Acids Research
Qian X, Nguyen HN, Song MM, et al. (2016) Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure. Cell
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