Max W. Chang, Ph.D.

Affiliations: 
2008 Bioinformatics University of California, San Diego, La Jolla, CA 
Area:
Adaptive knowledge representation
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Parents

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Richard Belew grad student 2008 UCSD
 (Computational structure-based methods to anticipate HIV drug resistance evolution and accelerate inhibitor discovery.)
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Publications

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Routh A, Chang MW, Okulicz JF, et al. (2015) CoVaMa: Co-Variation Mapper for disequilibrium analysis of mutant loci in viral populations using next-generation sequence data. Methods (San Diego, Calif.)
Flynn WF, Chang MW, Tan Z, et al. (2015) Deep sequencing of protease inhibitor resistant HIV patient isolates reveals patterns of correlated mutations in Gag and protease. Plos Computational Biology. 11: e1004249
Tiefenbrunn T, Forli S, Baksh MM, et al. (2013) Small molecule regulation of protein conformation by binding in the Flap of HIV protease. Acs Chemical Biology. 8: 1223-31
Chang MW, Oliveira G, Yuan J, et al. (2013) Rapid deep sequencing of patient-derived HIV with ion semiconductor technology. Journal of Virological Methods. 189: 232-4
Breuer S, Chang MW, Yuan J, et al. (2012) Identification of HIV-1 inhibitors targeting the nucleocapsid protein. Journal of Medicinal Chemistry. 55: 4968-77
Chang MW, Torbett BE. (2011) Accessory mutations maintain stability in drug-resistant HIV-1 protease. Journal of Molecular Biology. 410: 756-60
Chang MW, Ayeni C, Breuer S, et al. (2010) Virtual screening for HIV protease inhibitors: a comparison of AutoDock 4 and Vina. Plos One. 5: e11955
Chang MW, Giffin MJ, Muller R, et al. (2010) Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries. The Biochemical Journal. 429: 527-32
Chang MW, Belew RK, Carroll KS, et al. (2008) Empirical entropic contributions in computational docking: evaluation in APS reductase complexes. Journal of Computational Chemistry. 29: 1753-61
Chang MW, Lindstrom W, Olson AJ, et al. (2007) Analysis of HIV wild-type and mutant structures via in silico docking against diverse ligand libraries. Journal of Chemical Information and Modeling. 47: 1258-62
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