Paola Sacchetti, Ph.D.

Biology Mount Holyoke College, South Hadley, MA 
Parkinson's disease, nuclear receptors
"Paola Sacchetti"
Mean distance: 14.85 (cluster 11)


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Michael J. Bannon grad student 1996-2000 Wayne State
 (Positive and negative elements affecting the transcriptional expression of the human dopamine transporter gene.)
Philippe Lefebvre post-doc 2000-2005 INSERM
Ernest Arenas post-doc 2005-2009 Karolinska
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Theofilopoulos S, Wang Y, Kitambi SS, et al. (2013) Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. Nature Chemical Biology. 9: 126-33
Sacchetti P, Sousa KM, Hall AC, et al. (2009) Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells. Cell Stem Cell. 5: 409-19
Rawal N, Corti O, Sacchetti P, et al. (2009) Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling. Biochemical and Biophysical Research Communications. 388: 473-8
Wang Y, Sousa KM, Bodin K, et al. (2009) Targeted lipidomic analysis of oxysterols in the embryonic central nervous system. Molecular Biosystems. 5: 529-41
Andersson T, Södersten E, Duckworth JK, et al. (2009) CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells. The Journal of Biological Chemistry. 284: 3672-81
Carpentier R, Sacchetti P, Ségard P, et al. (2008) The glucocorticoid receptor is a co-regulator of the orphan nuclear receptor Nurr1. Journal of Neurochemistry. 104: 777-89
Sacchetti P, Carpentier R, Ségard P, et al. (2006) Multiple signaling pathways regulate the transcriptional activity of the orphan nuclear receptor NURR1. Nucleic Acids Research. 34: 5515-27
Jouault T, Ibata-Ombetta S, Takeuchi O, et al. (2003) Candida albicans phospholipomannan is sensed through toll-like receptors. The Journal of Infectious Diseases. 188: 165-72
Riachy R, Vandewalle B, Kerr Conte J, et al. (2002) 1,25-dihydroxyvitamin D3 protects RINm5F and human islet cells against cytokine-induced apoptosis: implication of the antiapoptotic protein A20. Endocrinology. 143: 4809-19
Sacchetti P, Dwornik H, Formstecher P, et al. (2002) Requirements for heterodimerization between the orphan nuclear receptor Nurr1 and retinoid X receptors. The Journal of Biological Chemistry. 277: 35088-96
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