Michael D. Varnum

Affiliations: 
Washington State University, Pullman, WA, United States 
Area:
Ion Channels
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"Michael Varnum"
Mean distance: 14.81 (cluster 11)
 
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Publications

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Meighan PC, Peng C, Varnum MD. (2015) Inherited macular degeneration-associated mutations in CNGB3 increase the ligand sensitivity and spontaneous open probability of cone cyclic nucleotide-gated channels. Frontiers in Physiology. 6: 177
Dai G, Sherpa T, Varnum MD. (2014) Alternative splicing governs cone cyclic nucleotide-gated (CNG) channel sensitivity to regulation by phosphoinositides. The Journal of Biological Chemistry. 289: 13680-90
Meighan SE, Meighan PC, Rich ED, et al. (2013) Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating. Biochemistry. 52: 8352-62
Liu C, Sherpa T, Varnum MD. (2013) Disease-associated mutations in CNGB3 promote cytotoxicity in photoreceptor-derived cells. Molecular Vision. 19: 1268-81
Dai G, Varnum MD. (2013) CNGA3 achromatopsia-associated mutation potentiates the phosphoinositide sensitivity of cone photoreceptor CNG channels by altering intersubunit interactions. American Journal of Physiology. Cell Physiology. 305: C147-59
Dai G, Peng C, Liu C, et al. (2013) Two structural components in CNGA3 support regulation of cone CNG channels by phosphoinositides. The Journal of General Physiology. 141: 413-30
Meighan PC, Meighan SE, Rich ED, et al. (2012) Matrix metalloproteinase-9 and -2 enhance the ligand sensitivity of photoreceptor cyclic nucleotide-gated channels. Channels (Austin, Tex.). 6: 181-96
Duricka DL, Brown RL, Varnum MD. (2012) Defective trafficking of cone photoreceptor CNG channels induces the unfolded protein response and ER-stress-associated cell death. The Biochemical Journal. 441: 685-96
Yamamoto BJ, Elias PD, Masino JA, et al. (2010) The angiotensin IV analog Nle-Tyr-Leu-psi-(CH2-NH2)3-4-His-Pro-Phe (norleual) can act as a hepatocyte growth factor/c-Met inhibitor. The Journal of Pharmacology and Experimental Therapeutics. 333: 161-73
Bright SR, Rich ED, Varnum MD. (2007) Regulation of human cone cyclic nucleotide-gated channels by endogenous phospholipids and exogenously applied phosphatidylinositol 3,4,5-trisphosphate. Molecular Pharmacology. 71: 176-83
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