James J. Treanor

Affiliations: 
Amgen Inc., Thousand Oaks, CA, United States 
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"James Treanor"
Mean distance: 16.78 (cluster 32)
 
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Publications

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Fox BM, Beck HP, Roveto PM, et al. (2015) A Selective Prostaglandin E2 Receptor Subtype 2 (EP2) Antagonist Increases the Macrophage-Mediated Clearance of Amyloid-Beta Plaques. Journal of Medicinal Chemistry. 58: 5256-73
Hwang DR, Hu E, Allen JR, et al. (2015) Radiosynthesis and initial characterization of a PDE10A specific PET tracer [(18)F]AMG 580 in non-human primates. Nuclear Medicine and Biology. 42: 654-63
Chen H, Lester-Zeiner D, Shi J, et al. (2015) AMG 580: a novel small molecule phosphodiesterase 10A (PDE10A) positron emission tomography tracer. The Journal of Pharmacology and Experimental Therapeutics. 352: 327-37
Rzasa RM, Frohn MJ, Andrews KL, et al. (2014) Synthesis and preliminary biological evaluation of potent and selective 2-(3-alkoxy-1-azetidinyl) quinolines as novel PDE10A inhibitors with improved solubility. Bioorganic & Medicinal Chemistry. 22: 6570-85
Hu E, Chen N, Bourbeau MP, et al. (2014) Discovery of clinical candidate 1-(4-(3-(4-(1H-benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A). Journal of Medicinal Chemistry. 57: 6632-41
Hu E, Andrews K, Chmait S, et al. (2014) Discovery of Novel Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A). Acs Medicinal Chemistry Letters. 5: 700-5
Hwang DR, Hu E, Rumfelt S, et al. (2014) Initial characterization of a PDE10A selective positron emission tomography tracer [11C]AMG 7980 in non-human primates. Nuclear Medicine and Biology. 41: 343-9
Hu E, Kunz RK, Chen N, et al. (2013) Design, optimization, and biological evaluation of novel keto-benzimidazoles as potent and selective inhibitors of phosphodiesterase 10A (PDE10A). Journal of Medicinal Chemistry. 56: 8781-92
Rzasa RM, Hu E, Rumfelt S, et al. (2012) Discovery of selective biaryl ethers as PDE10A inhibitors: improvement in potency and mitigation of Pgp-mediated efflux. Bioorganic & Medicinal Chemistry Letters. 22: 7371-5
Hu E, Kunz RK, Rumfelt S, et al. (2012) Use of structure based design to increase selectivity of pyridyl-cinnoline phosphodiesterase 10A (PDE10A) inhibitors against phosphodiesterase 3 (PDE3). Bioorganic & Medicinal Chemistry Letters. 22: 6938-42
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