Prescott Tarn Leach

Affiliations: 
Temple University, Philadelphia, PA, United States 
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"Prescott Leach"
Mean distance: 16.25 (cluster 19)
 
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William E. Fantegrossi research assistant 2003-2004 University of Michigan
Thomas J. Gould grad student 2008-2014 Temple University
 (Nicotine modulation of thyroid hormone signaling and its contribution to cognition.)
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Publications

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Leach PT, Kenney JW, Gould TJ. (2016) c-Jun-N-Terminal Kinase 1 (JNK1) is Necessary for Nicotine-Induced Enhancement of Contextual Fear Conditioning. Neuroscience Letters
Mandal M, Wu Y, Misiaszek J, et al. (2016) Structure-Based Design of an Iminoheterocyclic beta-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in non-Human Primates. Journal of Medicinal Chemistry
Leach PT, Gould TJ. (2015) Thyroid hormone signaling: Contribution to neural function, cognition, and relationship to nicotine. Neuroscience and Biobehavioral Reviews
Leach PT, Kenney JW, Connor DA, et al. (2015) Thyroid receptor β involvement in the effects of acute nicotine on hippocampus-dependent memory. Neuropharmacology. 93: 155-63
Leach PT, Kenney JW, Gould TJ. (2015) Stronger learning recruits additional cell-signaling cascades: c-Jun-N-terminal kinase 1 (JNK1) is necessary for expression of stronger contextual fear conditioning. Neurobiology of Learning and Memory. 118: 162-6
Leach PT, Holliday E, Kutlu MG, et al. (2015) Withdrawal From Chronic Nicotine Reduces Thyroid Hormone Levels and Levothyroxine Treatment Ameliorates Nicotine Withdrawal-Induced Deficits in Hippocampus-Dependent Learning in C57BL/6J Mice. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 17: 690-6
Gould TJ, Wilkinson DS, Yildirim E, et al. (2014) Nicotine shifts the temporal activation of hippocampal protein kinase A and extracellular signal-regulated kinase 1/2 to enhance long-term, but not short-term, hippocampus-dependent memory. Neurobiology of Learning and Memory. 109: 151-9
Gould TJ, Leach PT. (2014) Cellular, molecular, and genetic substrates underlying the impact of nicotine on learning. Neurobiology of Learning and Memory. 107: 108-32
Lotfipour S, Byun JS, Leach P, et al. (2013) Targeted deletion of the mouse α2 nicotinic acetylcholine receptor subunit gene (Chrna2) potentiates nicotine-modulated behaviors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 7728-41
Hyde LA, Zhang Q, Del Vecchio RA, et al. (2013) In Vivo Characterization of a Novel γ-Secretase Inhibitor SCH 697466 in Rodents and Investigation of Strategies for Managing Notch-Related Side Effects. International Journal of Alzheimer's Disease. 2013: 823528
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