John W. Regan

Neuroscience University of Arizona, Tucson, AZ 
Neuroscience Biology, Pharmacology, Cell Biology
"John Regan"
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Okura I, Hasuoka N, Senoo K, et al. (2021) The differential functional coupling of phosphodiesterase 4 to human DP and EP2 prostanoid receptors stimulated with PGD or PGE. Pharmacological Reports : Pr
Endo S, Suganami A, Fukushima K, et al. (2020) 15-keto-PGEacts as a biased/partial agonist to terminate PGE-evoked signaling. The Journal of Biological Chemistry
Kurata N, Tokashiki N, Fukushima K, et al. (2019) Short chain fatty acid butyrate uptake reduces expressions of prostanoid EP receptors and their mediation of cyclooxygenase-2 induction in HCA-7 human colon cancer cells. European Journal of Pharmacology. 853: 308-315
Seira N, Yamagata K, Fukushima K, et al. (2018) Cellular density-dependent increases in HIF-1α compete with c-Myc to down-regulate human EP4 receptor promoter activity through Sp-1-binding region. Pharmacology Research & Perspectives. 6: e00441
Araki Y, Suganami A, Endo S, et al. (2017) PGE1 and E3 show lower efficacies than E2 to β-catenin-mediated activity as biased ligands of EP4 prostanoid receptors. Febs Letters
Seira N, Yanagisawa N, Suganami A, et al. (2017) Anti-cancer Effects of MW-03, a Novel Indole Compound, by Inducing 15-Hydroxyprostaglandin Dehydrogenase and Cellular Growth Inhibition in the LS174T Human Colon Cancer Cell Line. Biological & Pharmaceutical Bulletin. 40: 1806-1812
Suganami A, Fujino H, Okura I, et al. (2016) Human DP and EP2 prostanoid receptors take on distinct forms depending on the diverse binding of different ligands. The Febs Journal
Fujino H, Seira N, Kurata N, et al. (2015) Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cells. European Journal of Pharmacology
Otake S, Yoshida K, Seira N, et al. (2015) Cellular density-dependent down-regulation of EP4 prostanoid receptors via the up-regulation of hypoxia-inducible factor-1α in HCA-7 human colon cancer cells. Pharmacology Research & Perspectives. 3: e00083
Oyama S, Fujino H, Yamazaki R, et al. (2014) A novel indole compound, AWT-489, inhibits prostaglandin D2-induced CD55 expression by acting on DP prostanoid receptors as an antagonist in LS174T human colon cancer cells. Archives of Biochemistry and Biophysics. 541: 21-9
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