Meredith Noetzel, Ph.D.

Affiliations: 
2009 Neuroscience University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
Neuroscience Biology, Pharmacology
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"Meredith Noetzel"
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Parents

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Esam E. El-Fakahany grad student 2009 UMN
 (The action of xanomeline on human muscarinic receptors expressed in Chinese hamster ovary cells.)
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Publications

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Wood MR, Noetzel MJ, Tarr JC, et al. (2016) Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition. Bioorganic & Medicinal Chemistry Letters
Wood MR, Noetzel MJ, Engers JL, et al. (2016) Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core. Bioorganic & Medicinal Chemistry Letters
Gould RW, Nedelcovych MT, Gong X, et al. (2015) State-Dependent Alterations in Sleep/wake Architecture Elicited by the M4 PAM VU0467154- Relation to Antipsychotic-like Drug Effects. Neuropharmacology
Malosh C, Turlington M, Bridges TM, et al. (2015) Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters
Ghoshal A, Rook JM, Dickerson JW, et al. (2015) Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Smith E, Chase P, Niswender CM, et al. (2015) Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4). Journal of Biomolecular Screening
Martín-Martín ML, Bartolomé-Nebreda JM, Conde-Ceide S, et al. (2015) Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5). Bioorganic & Medicinal Chemistry Letters. 25: 1310-7
Han C, Chatterjee A, Noetzel MJ, et al. (2015) Discovery and SAR of muscarinic receptor subtype 1 (M1) allosteric activators from a molecular libraries high throughput screen. Part 1: 2,5-dibenzyl-2H-pyrazolo[4,3-c]quinolin-3(5H)-ones as positive allosteric modulators. Bioorganic & Medicinal Chemistry Letters. 25: 384-8
Gentry PR, Kokubo M, Bridges TM, et al. (2014) Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380). Journal of Medicinal Chemistry. 57: 7804-10
Bubser M, Bridges TM, Dencker D, et al. (2014) Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents. Acs Chemical Neuroscience. 5: 920-42
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