Jeffrey M. Witkin

Affiliations: 
Eli Lilly, Indianapolis, IN, United States 
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"Jeffrey Witkin"
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Publications

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Knopp KL, Simmons RMA, Guo W, et al. (2019) Modulation of TARP γ8-containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain. The Journal of Pharmacology and Experimental Therapeutics
Witkin JM, Shenvi RA, Li X, et al. (2018) Pharmacological characterization of the neurotrophic sesquiterpene jiadifenolide reveals a non-convulsant signature and potential for progression in neurodegenerative disease studies. Biochemical Pharmacology
Witkin JM, Smith JL, Ping X, et al. (2018) Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABA receptors: Improved bioavailability enhances anticonvulsant efficacy. Neuropharmacology. 137: 332-343
Methuku KR, Li X, Cerne R, et al. (2018) An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABA receptors. Pharmacology, Biochemistry, and Behavior
Xu NZ, Ernst M, Treven M, et al. (2018) Negative allosteric modulation of alpha 5-containing GABAA receptors engenders antidepressant-like effects and selectively prevents age-associated hyperactivity in tau-depositing mice. Psychopharmacology
Bruns RF, Mitchell SN, Wafford KA, et al. (2017) Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders. Neuropharmacology
Witkin JM, Schober DA, Gleason SD, et al. (2017) Targeted Blockade of TARP-g8-Associated AMPA Receptors: Anticonvulsant Activity with the Selective Antagonist LY3130481 (CERC-611). Cns & Neurological Disorders Drug Targets
Kato AS, Witkin JM. (2017) Auxiliary subunits of AMPA receptors: the discovery of a forebrain-selective antagonist, LY3130481/CERC-611. Biochemical Pharmacology
Yuen E, Swanson S, Witkin JM. (2017) Prediction of human efficacious antidepressant doses using the mouse forced swim test. Pharmacology, Biochemistry, and Behavior
Lee MR, Gardinier KM, Gernert DL, et al. (2017) Structural Determinants of the γ-8 TARP Dependent AMPA Receptor Antagonist. Acs Chemical Neuroscience
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