Jeffrey M. Witkin
Affiliations: | Eli Lilly, Indianapolis, IN, United States |
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"Jeffrey Witkin"Mean distance: 17.34 (cluster 19) | S | N | B | C | P |
Parents
Sign in to add mentor| James E. Barrett | research assistant | University of Maryland | |
| Linda A. Dykstra | grad student | UNC Chapel Hill | |
| J. David Leander | post-doc | UNC Chapel Hill |
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Publications
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| Knopp KL, Simmons RMA, Guo W, et al. (2019) Modulation of TARP γ8-containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain. The Journal of Pharmacology and Experimental Therapeutics |
| Witkin JM, Shenvi RA, Li X, et al. (2018) Pharmacological characterization of the neurotrophic sesquiterpene jiadifenolide reveals a non-convulsant signature and potential for progression in neurodegenerative disease studies. Biochemical Pharmacology |
| Witkin JM, Smith JL, Ping X, et al. (2018) Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABA receptors: Improved bioavailability enhances anticonvulsant efficacy. Neuropharmacology. 137: 332-343 |
| Methuku KR, Li X, Cerne R, et al. (2018) An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABA receptors. Pharmacology, Biochemistry, and Behavior |
| Xu NZ, Ernst M, Treven M, et al. (2018) Negative allosteric modulation of alpha 5-containing GABAA receptors engenders antidepressant-like effects and selectively prevents age-associated hyperactivity in tau-depositing mice. Psychopharmacology |
| Bruns RF, Mitchell SN, Wafford KA, et al. (2017) Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders. Neuropharmacology |
| Witkin JM, Schober DA, Gleason SD, et al. (2017) Targeted Blockade of TARP-g8-Associated AMPA Receptors: Anticonvulsant Activity with the Selective Antagonist LY3130481 (CERC-611). Cns & Neurological Disorders Drug Targets |
| Kato AS, Witkin JM. (2017) Auxiliary subunits of AMPA receptors: the discovery of a forebrain-selective antagonist, LY3130481/CERC-611. Biochemical Pharmacology |
| Yuen E, Swanson S, Witkin JM. (2017) Prediction of human efficacious antidepressant doses using the mouse forced swim test. Pharmacology, Biochemistry, and Behavior |
| Lee MR, Gardinier KM, Gernert DL, et al. (2017) Structural Determinants of the γ-8 TARP Dependent AMPA Receptor Antagonist. Acs Chemical Neuroscience |