Paul C. Zamecnik

Affiliations: 
Harvard Medical School, Boston, MA, United States 
Area:
Protein biosynthesis and anti-sense DNA
Website:
http://www.fa.hms.harvard.edu/about-our-faculty/memorial-minutes/z/paul-charles-zamecnik/
Google:
"Paul Zamecnik"
Bio:

(1912 - 2009)
http://www.nasonline.org/member-directory/deceased-members/48834.html

Mean distance: 14.88 (cluster 11)
 
SNBCP
Cross-listing: Chemistry Tree

Parents

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Kaj Linderstrøm-Lang post-doc 1939-1940 University of Copenhagen (ID Tree)
Joseph C. Aub post-doc 1936-1941 Huntington Memorial Hospital
Max Bergmann post-doc 1941-1942 Rockefeller (Chemistry Tree)

Children

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Philip Siekevitz post-doc Harvard Medical School
Ivan D. Frantz research scientist 1947 Harvard Medical School (Chemistry Tree)
Mahlon Hoagland research scientist 1957 MGH

Collaborators

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Fritz Albert Lipmann collaborator MGH (Chemistry Tree)
BETA: Related publications

Publications

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Hoagland MB, Keller EB, Zamecnik PC. (2009) The mechanism of amino acid activation: the work of Mahlon Hoagland. 1956. The Journal of Biological Chemistry. 284: e7-8
Zhang S, Metelev V, Tabatadze D, et al. (2008) Near-infrared fluorescent oligodeoxyribonucleotide reporters for sensing NF-κB DNA interactions in vitro Oligonucleotides. 18: 235-243
Zhang S, Metelev V, Tabatadze D, et al. (2008) Fluorescence resonance energy transfer in near-infrared fluorescent oligonucleotide probes for detecting protein-DNA interactions. Proceedings of the National Academy of Sciences of the United States of America. 105: 4156-61
Tabatadze D, Zamecnik P, Yanachkov I, et al. (2008) A novel thymidine phosphoramidite synthon for incorporation of internucleoside phosphate linkers during automated oligodeoxynucleotide synthesis Nucleosides, Nucleotides and Nucleic Acids. 27: 157-172
Harth G, Zamecnik PC, Tabatadze D, et al. (2007) Hairpin extensions enhance the efficacy of mycolyl transferase-specific antisense oligonucleotides targeting Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 104: 7199-204
Elmaleh DR, Fischman AJ, Tawakol A, et al. (2006) Detection of inflamed atherosclerotic lesions with diadenosine-5',5'''-P1,P4-tetraphosphate (Ap4A) and positron-emission tomography. Proceedings of the National Academy of Sciences of the United States of America. 103: 15992-6
Zamecnik P. (2005) From protein synthesis to genetic insertion Annual Review of Biochemistry. 74: 1-28
Zamecnik PC, Raychowdhury MK, Tabatadze DR, et al. (2004) Reversal of cystic fibrosis phenotype in a cultured Delta508 cystic fibrosis transmembrane conductance regulator cell line by oligonucleotide insertion. Proceedings of the National Academy of Sciences of the United States of America. 101: 8150-5
Harth G, Horwitz MA, Tabatadze D, et al. (2002) Targeting the Mycobacterium tuberculosis 30/32-kDa mycolyl transferase complex as a therapeutic strategy against tuberculosis: Proof of principle by using antisense technology. Proceedings of the National Academy of Sciences of the United States of America. 99: 15614-9
Harth G, Zamecnik PC, Tang JY, et al. (2000) Treatment of Mycobacterium tuberculosis with antisense oligonucleotides to glutamine synthetase mRNA inhibits glutamine synthetase activity, formation of the poly-L-glutamate/glutamine cell wall structure, and bacterial replication. Proceedings of the National Academy of Sciences of the United States of America. 97: 418-23
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