Zhao-Bing Gao

Johns Hopkins University School of Medicine, Baltimore, MD, United States 
Ion channels
"Zhao-Bing Gao"
Mean distance: 15.37 (cluster 6)
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Zhang YM, Xu HY, Hu HN, et al. (2021) Discovery of HN37 as a Potent and Chemically Stable Antiepileptic Drug Candidate. Journal of Medicinal Chemistry
Xiang HY, Chen JY, Huan XJ, et al. (2020) Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 127710
Xiang HY, Wang X, Chen YH, et al. (2020) Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors. European Journal of Medicinal Chemistry. 112913
Xie ZQ, Tian XT, Zheng YM, et al. (2020) Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels. Acta Pharmacologica Sinica
Liao P, Qiu Y, Mo Y, et al. (2019) Selective activation of TWIK-related acid-sensitive K 3 subunit-containing channels is analgesic in rodent models. Science Translational Medicine. 11
Wang JT, Zheng YM, Chen YT, et al. (2019) Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core. Acta Pharmacologica Sinica
Tian F, Qiu Y, Lan X, et al. (2019) A small molecular compound selectively activates K2P channel TASK-3 by acting at two distant clusters of residues. Molecular Pharmacology
Wang L, Qiao GH, Hu HN, et al. (2019) Discovery of Novel Retigabine Derivatives as Potent KCNQ4 and KCNQ5 Channel Agonists with Improved Specificity. Acs Medicinal Chemistry Letters. 10: 27-33
Zhang X, Yin X, Zhang J, et al. (2019) High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer's disease mice National Science Review. 6: 1223-1238
Rodier E, Niday Z, Doci K, et al. (2018) Inhibition of KCNQ2/3 channels by HN38 and XE991 depends on the conformation of the outer vestibule. Molecular Pharmacology
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