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Dan P. Felsenfeld

Affiliations: 
Developmental and Regenerative Biology Icahn School of Medicine at Mount Sinai, New York, NY, United States 
Area:
Intergrin, L1, cell migration, video microscopy, laser trap, adhesion receptors, extracellular matrix, cytoskeleton
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"Dan Felsenfeld"
Bio:

Dan Felsenfeld received a bachelor's degree in Biochemistry from Harvard University (1982-6) and a PhD in Neurobiology from Tom Jessel's lab at Columbia University (1987-94). He then did postdoctoral training in Mike Sheetz' lab at Duke University. Since June 2000, he has been at the Mount Sinai Sinai School of Medicine (NY) and he is currently the Director of the High-Content Screening Shared Resource Facility.


Mean distance: 14 (cluster 11)
 		SNBCP
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Parents

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Thomas M. Jessell grad student 1987-1994 Columbia
Michael P. Sheetz post-doc 1994-2000 Duke (Chemistry Tree)

Children

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Melanie Cassella grad student 2008 Mount Sinai School of Medicine

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Publications

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Sakurai T, Gil OD, Whittard JD, et al. (2008) Interactions between the L1 cell adhesion molecule and ezrin support traction-force generation and can be regulated by tyrosine phosphorylation. Journal of Neuroscience Research. 86: 2602-14
Whittard JD, Sakurai T, Cassella MR, et al. (2006) MAP kinase pathway-dependent phosphorylation of the L1-CAM ankyrin binding site regulates neuronal growth. Molecular Biology of the Cell. 17: 2696-706
Okigaki M, Davis C, Falasca M, et al. (2003) Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration. Proceedings of the National Academy of Sciences of the United States of America. 100: 10740-5
Gil OD, Sakurai T, Bradley AE, et al. (2003) Ankyrin binding mediates L1CAM interactions with static components of the cytoskeleton and inhibits retrograde movement of L1CAM on the cell surface. The Journal of Cell Biology. 162: 719-30
Felsenfeld DP, Schwartzberg PL, Venegas A, et al. (1999) Selective regulation of integrin--cytoskeleton interactions by the tyrosine kinase Src. Nature Cell Biology. 1: 200-6
Sheetz MP, Felsenfeld D, Galbraith CG, et al. (1999) Cell migration as a five-step cycle. Biochemical Society Symposium. 65: 233-43
Sheetz MP, Felsenfeld DP, Galbraith CG. (1998) Cell migration: regulation of force on extracellular-matrix-integrin complexes. Trends in Cell Biology. 8: 51-4
Yauch RL, Felsenfeld DP, Kraeft SK, et al. (1997) Mutational evidence for control of cell adhesion through integrin diffusion/clustering, independent of ligand binding. The Journal of Experimental Medicine. 186: 1347-55
Choquet D, Felsenfeld DP, Sheetz MP. (1997) Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages. Cell. 88: 39-48
Felsenfeld DP, Choquet D, Sheetz MP. (1996) Ligand binding regulates the directed movement of beta1 integrins on fibroblasts. Nature. 383: 438-40
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