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David M. Holtzman

Affiliations: 
Neurology Washington University, Saint Louis, St. Louis, MO 
Area:
Alzheimer's, amyloid
Website:
http://neuro.wustl.edu/aboutus/facultybiographies/holtzman.htm
Google:
"David Holtzman"
Bio:

David Holtzman is the Andrew B. and Gretchen P. Jones Professor and Chairman of Neurology, Professor of Developmental Biology, Associate Director of the Alzheimer's Disease Research Center, and a member of the Hope Center for Neurological Disorders. A major interest in his lab is in understanding basic mechanisms underlying acute and chronic cell dysfunction in the CNS particularly as these mechanisms may relate to Alzheimer's disease (AD) and injury to the developing brain.

Mean distance: 14.48 (cluster 31)
 
Cross-listing: Alzheimer's Tree

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Publications

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Cignarella F, Filipello F, Bollman B, et al. (2020) TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis. Acta Neuropathologica
Wong MY, Lewis M, Doherty JJ, et al. (2020) 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner. Journal of Neuroinflammation. 17: 192
Gratuze M, Leyns CE, Sauerbeck AD, et al. (2020) Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration. The Journal of Clinical Investigation
Cable J, Holtzman DM, Hyman BT, et al. (2020) Alternatives to amyloid for Alzheimer's disease therapies-a symposium report. Annals of the New York Academy of Sciences
Zhou Y, Song WM, Andhey PS, et al. (2020) Author Correction: Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease. Nature Medicine
Sauerbeck AD, Gangolli M, Reitz SJ, et al. (2020) SEQUIN Multiscale Imaging of Mammalian Central Synapses Reveals Loss of Synaptic Connectivity Resulting from Diffuse Traumatic Brain Injury. Neuron
Davis AA, Inman CE, Wargel ZM, et al. (2020) genotype regulates pathology and disease progression in synucleinopathy. Science Translational Medicine. 12
Zhou Y, Song WM, Andhey PS, et al. (2020) Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease. Nature Medicine. 26: 131-142
Faraco G, Hochrainer K, Segarra SG, et al. (2020) Publisher Correction: Dietary salt promotes cognitive impairment through tau phosphorylation. Nature
Llibre-Guerra JJ, Li Y, Schindler SE, et al. (2019) Association of Longitudinal Changes in Cerebrospinal Fluid Total Tau and Phosphorylated Tau 181 and Brain Atrophy With Disease Progression in Patients With Alzheimer Disease. Jama Network Open. 2: e1917126
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