David M. Holtzman
Affiliations: | Neurology | Washington University, Saint Louis, St. Louis, MO |
Area:
Alzheimer's, amyloidWebsite:
http://neuro.wustl.edu/aboutus/facultybiographies/holtzman.htmGoogle:
"David Holtzman"Bio:
David Holtzman is the Andrew B. and Gretchen P. Jones Professor and Chairman of Neurology, Professor of Developmental Biology, Associate Director of the Alzheimer's Disease Research Center, and a member of the Hope Center for Neurological Disorders. A major interest in his lab is in understanding basic mechanisms underlying acute and chronic cell dysfunction in the CNS particularly as these mechanisms may relate to Alzheimer's disease (AD) and injury to the developing brain.
Mean distance: 14.48 (cluster 31)
Cross-listing: Alzheimer's Tree
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Publications
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Toral-Rios D, Long JM, Ulrich JD, et al. (2024) Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy. The Journal of Experimental Medicine. 221 |
Bosch ME, Dodiya HB, Michalkiewicz J, et al. (2024) Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner. Molecular Neurodegeneration. 19: 18 |
Carling GK, Fan L, Foxe NR, et al. (2024) Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model. Biorxiv : the Preprint Server For Biology |
Cadiz MP, Gibson KA, Todd KT, et al. (2024) Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations. The Journal of Experimental Medicine. 221 |
Vance JM, Farrer LA, Huang Y, et al. (2024) Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease. Annals of Neurology |
Seo DO, Holtzman DM. (2024) Current understanding of the Alzheimer's disease-associated microbiome and therapeutic strategies. Experimental & Molecular Medicine |
Chen Y, Song S, Parhizkar S, et al. (2023) APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread. Cell |
Litvinchuk A, Suh JH, Guo JL, et al. (2023) Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist. Neuron |
Tabor GT, Holtzman DM. (2023) Current status of amyloid-targeting immunotherapies for Alzheimer's disease. Science Translational Medicine. 15: eadk9993 |
Yin Z, Rosenzweig N, Kleemann KL, et al. (2023) APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints. Nature Immunology |