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Darell D. Bigner, M.D., Ph.D.

Affiliations: 
Pathology and Surgery Duke University, Durham, NC 
Area:
Neuro-Oncology
Website:
http://pathology.mc.duke.edu/neuropath/np_faculty_dbigner.htm
Google:
"Darell Bigner"
Bio:

1989 AANP President
MD, Duke University, PhD, Duke University
http://www.cancer.duke.edu/btc/docs/general/1.Wpreuss.pdf

Mean distance: 20.63 (cluster 32)
 
Cross-listing: Neuropathology Tree

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Publications

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Sun MA, Yang R, Liu H, et al. (2023) Repurposing Clemastine to Target Glioblastoma Cell Stemness. Cancers. 15
Thompson EM, Landi D, Brown MC, et al. (2023) Recombinant polio-rhinovirus immunotherapy for recurrent paediatric high-grade glioma: a phase 1b trial. The Lancet. Child & Adolescent Health
Parker S, McDowall C, Sanchez-Perez L, et al. (2023) Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models. Science Translational Medicine. 15: eabn5649
Gromeier M, Brown MC, Zhang G, et al. (2021) Very low mutation burden is a feature of inflamed recurrent glioblastomas responsive to cancer immunotherapy. Nature Communications. 12: 352
Mosaheb MM, Dobrikova EY, Brown MC, et al. (2020) Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity. Nature Communications. 11: 524
Desjardins A, Randazzo D, Chandramohan V, et al. (2020) Phase I trial of D2C7 immunotoxin (D2C7-IT) administered intratumorally via convection-enhanced delivery (CED) for recurrent malignant glioma (MG). Journal of Clinical Oncology. 38: 2566-2566
Chandramohan V, Bao X, Yu X, et al. (2019) Improved efficacy against malignant brain tumors with EGFRwt/EGFRvIII targeting immunotoxin and checkpoint inhibitor combinations. Journal For Immunotherapy of Cancer. 7: 142
Hansen LJ, Sun R, Yang R, et al. (2019) MTAP loss promotes stemness in glioblastoma and confers unique susceptibility to purine starvation. Cancer Research
Yu X, Dobrikov M, Keir ST, et al. (2019) Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors. Plos One. 14: e0210608
Lipp ES, Healy P, Austin A, et al. (2019) MGMT: Immunohistochemical Detection in High-Grade Astrocytomas. Journal of Neuropathology and Experimental Neurology. 78: 57-64
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