Calderon-Garciduenas Lilian, MD UNAM 1971, PhD University of North Carolina Chapel Hill

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BIOGRAPHICAL SKETCH
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NAME
Lilian Calderón-Garcidueñas POSITION TITLE
Associate Professor
eRA COMMONS USER NAME
lcalderon
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION DEGREE
(if applicable) YEAR(s) FIELD OF STUDY
Universidad Veracruzana B.S. 1967 Biology
Faculty of Medicine, UNAM, Mexico City M.D. 1972 Medicine
U Boston, U Toronto, Harvard University, U Mass Intern, Resident 1975-1981 Pathology, Neuropathology
American Board in Pathology and Neuropathology Fellow 1981 Pathology, Neuropathology
Univ. North Carolina, Chapel Hill, N.C. Ph.D. 1997-2001 Toxicology
Univ. North Carolina, Chapel Hill, N.C. Postdoc 2001-2004 Environmental Pathology





A. Positions & Honors

Positions and Employment
1975 - 1976 Mixed Internship, Framingham Union Hospital, Boston University, Framingham, Mass, USA
1976 - 1977 Residency in Anatomical Pathology, St Michael's Hospital, University of Toronto, Toronto, C Canada
1977 - 1978 Residency Anatomical Pathology, Banting Institute, University of Toronto, Toronto, Canada
1978 - 1979 Residency Neuropathology, Toronto Western Hospital, University of Toronto, Toronto, Canada
1979 - 1980 Pediatric Neuropathology Residency, Harvard University, Children's Hospital Medical Center, Boston, Mass
1980 - 1981 Chief Resident, Anatomical Pathology Residency, University of Mass at Worcester, Worcester, Mass
1981 - 1981 Chief Resident Elective Rotation: Massachusetts Eye and Ear Infirmary, Howe Laboratory, Boston, Mass
1981 - 1985 Assistant Professor of Pathology and Neurology, Northwestern University, Chicago, Ill
1985 - 1986 Pathologist, Instituto Nacional de Perinatologia, Mexico City
1986 - 1989 English Literature and Comparative Literature UNAM student degrees awarded: BA and MA
1989 - 1991 Chief Medical Research and Medical Education Office, Naval Medical Center, Mexico
1991 - 1993 Senior Researcher, Atmospheric Science Center, National University of Mexico, UNAM
1993 - 1997 Chief Experimental Pathology Laboratory, National Institute of Pediatrics, Mexico
1997 - 2001 Doctoral student Toxicology Curriculum, University of North Carolina at Chapel Hill
2001 - 2004 Postdoctoral Fellow Environmental Pathology, University of North Carolina at Chapel Hill
2004 -2008 Assistant Professor of Neurotoxicology and Environmental Pathology, University of Montana
2008-to date Associate Professor of Neurotoxicology and Environmental Pathology, University of Montana

Honors
Outstanding Student Award, Veracruz University 1967
Cum Laude, Faculty of Medicine, UNAM, Mexico 1972
George Van Myer Award in recognition of excellence in Residency Training, The Children’s Hospital Medical Center, Boston, Mass.
Northwestern University Teaching Award, 1984
Navy Award for Excellence in Clinical Research, 1990
National Environmental Health Award "Matilde M de Santos", 1994, 1998, 2002, 2006 (Mexico)
Award to the Best Teacher at the Instituto Tecnológico de Monterrey, Mexico City 1995
Best Graduate Student Inhalation Toxicology Award, Society of Toxicology, Chapter North Carolina, USA, March 1998
Travel Award American Society for Investigative Pathology 2000
ASIP Trainee representative to the Long Range Planning Committee 2002-2003
2002 Excellence in Research Presentation Award, Department of Pathology and Laboratory Medicine, School of Medicine, University of North Carolina, September 19, 2002
Carol R. Angle Young Investigator Award, December 2003, Chapel Hill, N.C.
National Environmental Award, Fundaciόn Mexicana para la Salud, Academy of Medicine, Mexico City, Mexico November 14, 2006

Professional Society Memberships
American Board of Pathology and Neuropathology 1981
American Society for Investigative Pathology (ASIP) 1992
American Thoracic Society (ATS) 1995
American Association of Neuropathologists (AANP) 2003
Montana Medical Association 2005
The Society of Toxicological Pathology 2007
Medical License: Montana Medical Registration # 10707 Active 1999-to date



B. Selected peer-reviewed publications (in chronological order).
1. Calderon-Garcidueñas L., Osorno-Velazquez A., Bravo-Alvarez H., Delgado Chavez R., Barrios-Marquez R. Histopathological Changes of the Nasal Mucosa in Southwest Metropolitan Mexico City Inhabitants. Am J Pathol 140:225-232,1992.
2. Calderón-Garcidueñas L., Hernandez-Martinez A., Bravo-Alvarez H. Nasal Cytology in Southwest Metropolitan Mexico City Inhabitants. Airwaste Management Assoc 146:2-8,1992
3. Calderón-Garcidueñas L., Roy-Ocotla G. Nasal Cytology in Southwest Metropolitan Mexico City Inhabitants: A Pilot Intervention Study. Environm Health Persp 101:138-144,1993.
4. Calderón-Garcidueñas L., Duran-Chavez C., Camacho-Carmona R., García-Alvarez R., Barragan-Mejía G. CD11b Upregulation in nasal polymorphonuclear leukocytes as a potential marker of atmospheric pollutant exposure. J Exp Analysis Environm Epidemiol 4:477-489,1994
5. Calderón-Garcidueñas L., Rodriguez-Alcaraz A., Garcia R., Sanchez G., Barragan G., Camacho R., Ramirez L. Human Nasal Mucosal Changes after exposure to Urban Pollution. Environm Health Persp 102: 1074-1080, 1994
6. Calderon-Garcidueñas L., Rodriguez-Alcaraz A., García R., Ramirez L., Barragan G. Nasal Inflammatory Responses in Children Exposed to a Polluted Urban Atmosphere. J Toxicol Environm Health 45:427-437,1995
7. Calderón-Garcidueñas L., Osnaya N., Ramirez L., Villarreal A. DNA strand breaks in human nasal respiratory epithelium are induced upon exposure to urban pollution. Environ Health Perspect 104:160-168, 1996.
8. Calderón-Garcidueñas L., Osnaya N., Rodriguez-Alcaraz A., Villarreal A. DNA strand breaks in Nasal Respiratory Epithelium from Children Exposed to Urban Pollution. Environmental and Molecular Mutagenesis, 1997;30:11-20
9. Calderón-Garcidueñas L., Rodríguez-Alcaraz A, Villarreal A, Lyght O, Janszen D, Morgan KT. Nasal Epithelium as a Sentinel for Airborne Environmental Pollution. Toxicological Sciences, 1998;46:352-364
10. Calderón-Garcidueñas L., Rodríguez-Alcaraz A, Garcia R, Barragan G, Villarreal A et al. Cell proliferation in nasal respiratory epithelium of people exposed to urban pollution. Carcinogenesis 1999;20:383-389.
11. Calderón-Garcidueñas L, Wen-Wang L, Zhang YJ, Osnaya N, Garcia R, et al. 8-Hydroxy-2' deoxiguanosine, a major mutagenic oxidative DNA lesion, and DNA strand breaks in nasal respiratory epithelium of children exposed to urban pollution. Environ Health Perspect 1999;107:469-474.
12. Calderón-Garcidueñas L, Delgado R, Calderón-Garcidueñas A, Meneses A, Ruiz LM, de la Garza J, Acuna H, Villarreal A., Raab-Traub N, Devlin RB. Malignant neoplasms of the nasal cavity and paranasal sinuses. A series of 256 patients in Mexico City and Monterrey. Is air pollution the missing link? Otolaryngology Head and Neck Surgery 2000;122:499-508.
13. Calderón-Garcidueñas L, Mora-Tiscareno A, Chung CJ, Valencia-Salazar G., Fordham LA, Garcia R, Osnaya N, Romero L, Acuna H, Villarreal A., Devlin RB, Koren HS. Exposure to air pollution is associated with lung hyperinflation in healthy children and adolescents in Southwest Mexico City. A Pilot Study. Inhalation Toxicol 2000;12:537-561
14. Calderón-Garcidueñas L, Devlin RB, Miller FJ. Respiratory tract pathology and cytokine misbalance and overproduction in clinically healthy children chronically and sequentially exposed to air pollutants. Medical Hypothesis 2000;55:373-378
15. Calderón-Garcidueñas L, Valencia-Salazar G, Rodriguez-Alcaraz A, Gambling TM, Garcia R, Osnaya N, Villarreal A, Devlin RB, Carson JL. Ultrastructural nasal pathology in children chronically and sequentially exposed to air pollutants. Am J Respir Cell Mol Biol 2001;24:132-138
16. Moss OR, Gross EA, James RA, Janszen DB, Ross PW, Roberts KC, Howard AM, Harkema JR, Calderón-Garcidueñas L, Morgan KT. Respiratory tract toxicity in rats exposed to Mexico City air. Res Rep Health Eff Inst 2001; Mar(100):1-24
17. Calderón-Garcidueñas L, Mora-Tiscareno A, Fordham L, Chung CH, et al. Canines as Sentinel Species for Assessing Chronic Exposures to Air pollutants. Respiratory Pathology. Toxicol Sci 2001;61:342-355
18. Calderón-Garcidueñas L, Gambling TM, Acuna H, Garcia R, Osnaya N, et al. Canines as Sentinel Species for Assessing Chronic Exposures to Air pollutants. Cardiac Pathology. Toxicol Sciences 2001; 61:356-367
19. Calderón-Garcidueñas L, Valencia-Salazar G, Rodriguez-Alcaraz A, et al. p53 in nasal biopsies of children chronically and sequentially exposed to air pollutants. Toxicol Path 2001;29:558-564
20. Amador Zarco JJ, Mora-Tiscareno A, Sangri-Pinto AG, Calderón-Garcidueñas L. Nasal squamous cell carcinoma in a child. J Otolaryngology 2002;31:45-49
21. Villarreal A, Acuña H, Garduño M, Henriquez-Roldan CF, Calderón-Garcidueñas L, Valencia -Salazar G. Assessment of physical education time and outdoor time in elementary and middle school students in South Mexico City: The dilemma between physical fitness and the adverse effects of outdoor pollutant exposure. Arch Environ Health 2002;57:450-460
22. Calderón-Garcidueñas L, Azzarelli B, Acuna H, Garcia R, Gambling TM, Osnaya N, Monroy S, Tizapantzi MR, Villarreal A. Air Pollution and Brain Damage. Tox Path 2002;30:373-389
23. Calderón-Garcidueñas L, et al. Respiratory damage in children exposed to urban pollution. Pediatric Pulmonol 2003:36:148-161
24. Calderón-Garcidueñas L, et al. DNA damage in nasal and brain tissues of canines exposed to air pollutants is associated with evidence of chronic brain inflammation and neurodegeneration. Toxicol Pathol 2003:31:524-538
25. Calderón-Garcidueñas L, et al. Brain inflammation and Alzheimer’s-like pathology in individuals exposed to severe air pollution. Tox Pathol 2004;32:650-658
26. Calderon-Garciduenas L, Mora-Tiscareno A, Fordham LA, Chung CJ, Valencia-Salazar G, Flores-Gomez S, Solt AC, Gomez-del Campo A, Jardon-Torres R, Henriquez-Roldan C, Hazucha MJ, Reed W. Lung radiology and pulmonary function of children chronically exposed to air pollution. Environ Health Perspect. 2006 Sep;114(9):1432-7.
27. Peters A, Veronesi B, Calderon-Garciduenas L, Gehr P, Chen LC, Geiser M, Reed W, Rothen-Rutishauser B, Schurch S, Schulz H. Translocation and potential neurological effects of fine and ultrafine particles a critical update. Part Fibre Toxicol. 2006 Sep 8;3:13.
28. Calderon-Garciduenas L, Franco-Lira M, Jardon-Torres R, Henriquez-Roldan C, Barragan-Mejia G, Valencia-Salazar G, Gonzalez-Maciel A, Reynoso-Robles R, Villarreal-Calderon R, Reed W.Pediatric respiratory and systemic effects of chronic air pollution exposure: nose,lung,heart, and brain pathology.Toxicol Pathol 2007; 35:154-162
29. He W, Greenwell RJ, Brooks DM, Calderón-Garcidueñas L, Beall HD, Coffin JD. Arsenic exposure in pregnant mice disrupts placental vasculogenesis and causes spontaneous abortion. Toxicol Sci 2007; 99:244-253
30. Thomson EM, Kumarathasan P, Calderón-Garcidueñas L, Vincent R. Air pollution alters brain and pituitary endothelin-1 and inducible nitric oxide synthase gene expression. Environ Res 2007; 105:224-233
31. Calderón-Garcidueñas L,Vincent R, Mora-Tiscareno A,Franco-Lira M, Henriquez-Roldan C, Barragan-Mejia G, Garrido-Garcia L, Camacho-Reyes L, Valencia-Salazar G, Paredes R, Romero L, Osnaya H, Villarreal-Calderon R, Torres-Jardon R, Hazucha MJ, Reed W. Elevated plasma endothelin-1 and pulmonary arterial pressure in children exposed to air pollution. Environ Health Perspect 2007; 115:1248-1253
32. Calderón-Garcidueñas L,Solt A, Henriquez-Roldan C, Torres-Jardon R, Nuse B, Herritt L, Stone I. Long-term air pollution exposure is associated with neuroinflammation , an altered innate immune response, disruption of the blood-brain-barrier, ultrafine particle deposition, and accumulation of amyloid β42 and α synuclein in children and young adults. Toxicol Pathol 2008;36:289-310
33. Calderón-Garcidueñas L, Calderón-Garcidueñas L, Mora-Tiscareño A, Ontiveros E, Gómez-Garza G, Barragán-Mejía G, Broadway J, Chapman S, Valencia-Salazar G, Jewells V, Maronpot RR, Henríquez-Roldán C, Pérez-Guillé B, Torres-Jardón R, Herrit L, Brooks D, Osnaya-Brizuela N, Monroy ME, González-Maciel A, Reynoso-Robles R, Villarreal-Calderon R, Solt AC, Engle RW. Air pollution, cognitive deficits and brain abnormalities: A pilot study with children and dogs. Brain and Cognition 2008 on line
34. Pfau JC, Sentissi JJ, Li S, Calderon-Garciduenas L, Brown JM, Blake DJ. Asbestos induced autoimmunity in C57BL/6 mice. J Immunotox 2008; 5:129-137
35. Calderón-Garcidueñas L, Villarreal-Calderon R, Valencia-Salazar G, Henriquez-Roldan C, Gutierrez-Castrellon P, Torres-Jardon R, Osnaya-Brizuela N, Romero L, Coria-Jimenez R, Solt A, Reed W. Systemic inflammation, endothelial dysfunction, and activation in clinically healthy children exposed to air pollutants. Inhal Toxicol 2008;20:499-506

Book Chapters
Calderón-Garcidueñas L, Noah TL, Koren HS. Novel approaches to study nasal responses to air pollution. In: Air Pollution and Health. Academic Press 1999
Calderón-Garcidueñas L, Reed W. Air pollution and human brain pathology: a role for air pollutants in the patthogenesis of Alzheimer’s disease. In: Particle Toxicology, editors: K Donaldson and Paul Borm, CRC Press 2007

C. Research Support

Ongoing Research Support

ITHS WWAMI NIH The University of Washington Award
Calderon-Garciduenas Lilian (PI) 09/23/2008 - 09/22/2009
NIH 10,000.00
Air pollution and neuroinflammation in children and young adults
The objective of this research is to characterize vascular inflammation and neuroinflammatory responses in children exposed to air pollution.


Center for Structural and Functional Neuroscience CSFN
Calderon-Garciduenas Lilian (PI) 09/1/08 - 08/31/09
NIH COBRE 15,000.00
Brain-soluble oligomers of the amyloid β-protein in urban children and young adults
The objective of this research is to characterize and quantify the soluble oligomers of the amyloid β-protein in two crucial target brain areas: frontal and temporal cortex, using autopsy samples of children and young adults exposed to severe versus low urban air pollution.

5 KO1 NS046410-04 Calderon-Garciduenas (PI) 09/15/04 - 08/31/09
NIH NINDS
Air Pollution and Central Nervous System Disease
Goal is to establish a firm scientific basis to the link between air pollution and brain alterations, including defining the role of oxidative DNA damage in neurodevelopment and neurodegeneration, determining if there are quantitative changes in RT-PCR expression of inflammatory modulators and stress response proteins, determining their potential association with biomarkers of oxidative damage, and defining the neuropathology component of this environmental disease. Also crucial is the exploration of fetal CNS developmental effects in bitches exposed to air pollutants.
Role: PI

Completed Research Support
MRA003 0245094 Kukuk (PI) 08/11/03 - 08/31/07
NSF ADVANCE
The University of Montana Partnership for Comprehensive Equity - UM PACE
This project is designed to change policy, increase the number of tenure-line women on the faculty, empower faculty, and create a statewide network of women scientists.
Role: Collaborator

1 R21 ES013293-03A1 Calderon-Garciduenas (PI) 08/22/05 - 07/31/08
NIH NIEHS Currently on no-cost extension
Neurotoxicity of Chronic Exposure to Air Pollution
The objective of this research is to strengthen the association between exposure to air pollution and brain inflammation and neurodegenerative pathology.

Role: PI
1R56 ES016002-01 Calderón-Garcidueñas (PI) 09/29/07 – 08/31/08
NIH NIEHS
Air Pollution Effects on Children’s Brain Pathology, Structure & Function
The objective of this research is to evaluate the presence of white matter lesions in healthy children with no known risk factors for neurological or cognitive alterations in two cohorts of matched 6 year olds exposed to high (n:20) or low (n:20) levels of urban air pollution.
Role: PI





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