William W. Schlaepfer, MD, Yale University
Affiliations: | Pathology and Laboratory Medicine | University of Pennsylvania, Philadelphia, PA, United States |
Area:
structural, biochemical and molecular properties of neurofilament (NF) proteinsWebsite:
http://pathology.uphs.upenn.edu/Faculty/FacultyInfo.aspx?site=FacultyList&dept=Faculty&id=4753Google:
"William Schlaepfer"Bio:
1986 AANP President
Mean distance: 16.91 (cluster 24)
Cross-listing: Chemistry Tree
Children
Sign in to add trainee| Lawrence C. Kenyon | grad student | Penn | |
| Maria Martinez-Lage | grad student | 2010-2012 | Penn (Neuropathology Tree) |
| Pallavi P. Gopal | post-doc | Penn | |
| Edward B. Lee | post-doc | Penn |
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Publications
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| Zhai J, Lin H, Julien JP, et al. (2007) Disruption of neurofilament network with aggregation of light neurofilament protein: a common pathway leading to motor neuron degeneration due to Charcot-Marie-Tooth disease-linked mutations in NFL and HSPB1. Human Molecular Genetics. 16: 3103-16 |
| Lin H, Schlaepfer WW. (2006) Role of neurofilament aggregation in motor neuron disease. Annals of Neurology. 60: 399-406 |
| Lin H, Zhai J, Schlaepfer WW. (2005) RNA-binding protein is involved in aggregation of light neurofilament protein and is implicated in the pathogenesis of motor neuron degeneration. Human Molecular Genetics. 14: 3643-59 |
| Lin H, Zhai J, Cañete-Soler R, et al. (2004) 3' untranslated region in a light neurofilament (NF-L) mRNA triggers aggregation of NF-L and mutant superoxide dismutase 1 proteins in neuronal cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2716-26 |
| Lin H, Zhai J, Nie Z, et al. (2003) Neurofilament RNA causes neurodegeneration with accumulation of ubiquitinated aggregates in cultured motor neurons. Journal of Neuropathology and Experimental Neurology. 62: 936-50 |
| Ge W, Wu J, Zhai J, et al. (2002) Binding of p190RhoGEF to a destabilizing element on the light neurofilament mRNA is competed by BC1 RNA. The Journal of Biological Chemistry. 277: 42701-5 |
| Nie Z, Wu J, Zhai J, et al. (2002) Untranslated element in neurofilament mRNA has neuropathic effect on motor neurons of transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7662-70 |
| Zhai J, Lin H, Shamim M, et al. (2001) Identification of a novel interaction of 14-3-3 with p190RhoGEF. The Journal of Biological Chemistry. 276: 41318-24 |
| Cañete-Soler R, Wu J, Zhai J, et al. (2001) p190RhoGEF Binds to a destabilizing element in the 3' untranslated region of light neurofilament subunit mRNA and alters the stability of the transcript. The Journal of Biological Chemistry. 276: 32046-50 |
| Cañete-Soler R, Schlaepfer WW. (2000) Similar poly(C)-sensitive RNA-binding complexes regulate the stability of the heavy and light neurofilament mRNAs. Brain Research. 867: 265-79 |