Martin J. Humphries, B.Sc., Ph.D.

Affiliations: 
Wellcome Trust Center for Cell-Matrix Research Manchester University, North Manchester, IN, United States 
Area:
Integrin structure and signaling
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"Martin Humphries"
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Publications

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Lončarić M, Stojanović N, Rac-Justament A, et al. (2023) Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line. Cellular & Molecular Biology Letters. 28: 56
Humphries JD, Zha J, Burns J, et al. (2022) Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation. Matrix Biology : Journal of the International Society For Matrix Biology
Hamalian S, Güth R, Runa F, et al. (2021) A SNAI2-PEAK1-INHBA stromal axis drives progression and lapatinib resistance in HER2-positive breast cancer by supporting subpopulations of tumor cells positive for antiapoptotic and stress signaling markers. Oncogene
Gough RE, Jones MC, Zacharchenko T, et al. (2021) Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1. The Journal of Biological Chemistry. 100837
Chastney MR, Lawless C, Humphries MJ. (2020) Multiplexed Proximity Biotinylation Coupled to Mass Spectrometry for Defining Integrin Adhesion Complexes. Current Protocols in Cell Biology. 88: e113
Samaržija I, Dekanić A, Humphries JD, et al. (2020) Integrin Crosstalk Contributes to the Complexity of Signalling and Unpredictable Cancer Cell Fates. Cancers. 12
Chastney MR, Lawless C, Humphries JD, et al. (2020) Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation. The Journal of Cell Biology. 219
Paradžik M, Humphries JD, Stojanović N, et al. (2020) KANK2 Links αVβ5 Focal Adhesions to Microtubules and Regulates Sensitivity to Microtubule Poisons and Cell Migration. Frontiers in Cell and Developmental Biology. 8: 125
Randles MJ, Lausecker F, Humphries JD, et al. (2020) Basement membrane ligands initiate distinct signalling networks to direct cell shape. Matrix Biology : Journal of the International Society For Matrix Biology
Chen Y, Kong F, Li Z, et al. (2020) Distinctive Mechano-sensitivity of Focal Adhesion Integrins α5β1 and αVβ3 in Conformational Changes Biophysical Journal. 118
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