Derrick F. MacFabe, MD

Psychology University of Western Ontario, London, Ontario, Canada 
animal models-autism
"Derrick MacFabe"
Mean distance: 18.53 (cluster 19)
Cross-listing: PsychTree

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Meeking MM, MacFabe DF, Mepham JR, et al. (2019) Propionic acid induced behavioural effects of relevance to autism spectrum disorder evaluated in the hole board test with rats. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 109794
Mepham JR, Boon FH, Foley KA, et al. (2019) Impaired Spatial Cognition in Adult Rats Treated with Multiple Intracerebroventricular (ICV) Infusions of the Enteric Bacterial Metabolite, Propionic Acid, and Return to Baseline After 1 Week of No Treatment: Contribution to a Rodent Model of ASD. Neurotoxicity Research
Shams S, Foley KA, Kavaliers M, et al. (2019) Systemic treatment with the enteric bacterial metabolic product propionic acid results in reduction of social behavior in juvenile rats: Contribution to a rodent model of autism spectrum disorder. Developmental Psychobiology
Shultz SR, Aziz NA, Yang L, et al. (2015) Intracerebroventricular injection of propionic acid, an enteric metabolite implicated in autism, induces social abnormalities that do not differ between seizure-prone (FAST) and seizure-resistant (SLOW) rats. Behavioural Brain Research. 278: 542-8
Foley KA, MacFabe DF, Kavaliers M, et al. (2015) Sexually dimorphic effects of prenatal exposure to lipopolysaccharide, and prenatal and postnatal exposure to propionic acid, on acoustic startle response and prepulse inhibition in adolescent rats: relevance to autism spectrum disorders. Behavioural Brain Research. 278: 244-56
Nankova BB, Agarwal R, MacFabe DF, et al. (2014) Enteric bacterial metabolites propionic and butyric acid modulate gene expression, including CREB-dependent catecholaminergic neurotransmission, in PC12 cells--possible relevance to autism spectrum disorders. Plos One. 9: e103740
Foley KA, MacFabe DF, Vaz A, et al. (2014) Sexually dimorphic effects of prenatal exposure to propionic acid and lipopolysaccharide on social behavior in neonatal, adolescent, and adult rats: implications for autism spectrum disorders. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 39: 68-78
Foley KA, Ossenkopp KP, Kavaliers M, et al. (2014) Pre- and neonatal exposure to lipopolysaccharide or the enteric metabolite, propionic acid, alters development and behavior in adolescent rats in a sexually dimorphic manner. Plos One. 9: e87072
Frye RE, Melnyk S, Macfabe DF. (2013) Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder. Translational Psychiatry. 3: e220
Thomas RH, Meeking MM, Mepham JR, et al. (2012) The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders. Journal of Neuroinflammation. 9: 153
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