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Charlie Y. Hsu, Ph.D.

Affiliations: 
2012 Biomedical Engineering University of Alberta, Edmonton, Alberta, Canada 
Area:
Biomedical Engineering
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"Charlie Hsu"
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Hasan Uludag grad student 2012 University of Alberta
 (Mechanistic studies on the uptake and intracellular trafficking of DNA complexes in primary cells using lipid-modified cationic polymers as non-viral gene carrier.)

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Wang Y, Mostafa NZ, Hsu CY, et al. (2013) Modification of human BMSC with nanoparticles of polymeric biomaterials and plasmid DNA for BMP-2 secretion. The Journal of Surgical Research. 183: 8-17
Hsu CY, Uludağ H. (2012) Cellular uptake pathways of lipid-modified cationic polymers in gene delivery to primary cells. Biomaterials. 33: 7834-48
Hsu CY, Uludağ H. (2012) A simple and rapid nonviral approach to efficiently transfect primary tissue-derived cells using polyethylenimine. Nature Protocols. 7: 935-45
Aliabadi HM, Landry B, Mahdipoor P, et al. (2012) Effective down-regulation of breast cancer resistance protein (BCRP) by siRNA delivery using lipid-substituted aliphatic polymers. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 81: 33-42
Hsu CY, Uludağ H. (2012) Nucleic-acid based gene therapeutics: delivery challenges and modular design of nonviral gene carriers and expression cassettes to overcome intracellular barriers for sustained targeted expression. Journal of Drug Targeting. 20: 301-28
Hsu CY, Hendzel M, Uludaǧ H. (2011) Improved transfection efficiency of an aliphatic lipid substituted 2 kDa polyethylenimine is attributed to enhanced nuclear association and uptake in rat bone marrow stromal cell. The Journal of Gene Medicine. 13: 46-59
Neamnark A, Suwantong O, Bahadur RK, et al. (2009) Aliphatic lipid substitution on 2 kDa polyethylenimine improves plasmid delivery and transgene expression. Molecular Pharmaceutics. 6: 1798-815
Clements BA, Hsu CY, Kucharski C, et al. (2009) Nonviral delivery of basic fibroblast growth factor gene to bone marrow stromal cells. Clinical Orthopaedics and Related Research. 467: 3129-37
Abbasi M, Uludag H, Incani V, et al. (2008) Further investigation of lipid-substituted poly(L-Lysine) polymers for transfection of human skin fibroblasts. Biomacromolecules. 9: 1618-30
Hsu CY, Uludağ H. (2008) Effects of size and topology of DNA molecules on intracellular delivery with non-viral gene carriers. Bmc Biotechnology. 8: 23
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