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David J. Brick, Ph.D.

Affiliations: 
2001 University of Victoria, Victoria, British Columbia, Canada 
Area:
Microbiology Biology, Biochemistry
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Chris Upton grad student 2001 University of Victoria
 (Molecular characterization of poxviral RING finger proteins: Virosome localization and identification of DNA binding and apoptosis inhibition activity.)

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Publications

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Jin L, Perng GC, Carpenter D, et al. (2007) Reactivation phenotype in rabbits of a herpes simplex virus type 1 mutant containing an unrelated antiapoptosis gene in place of latency-associated transcript. Journal of Neurovirology. 13: 78-84
Jin L, Perng GC, Mott KR, et al. (2005) A herpes simplex virus type 1 mutant expressing a baculovirus inhibitor of apoptosis gene in place of latency-associated transcript has a wild-type reactivation phenotype in the mouse. Journal of Virology. 79: 12286-95
Peng W, Jin L, Henderson G, et al. (2004) Mapping herpes simplex virus type 1 latency-associated transcript sequences that protect from apoptosis mediated by a plasmid expressing caspase-8. Journal of Neurovirology. 10: 260-5
Jin L, Perng GC, Brick DJ, et al. (2004) Methods for detecting the HSV-1 LAT anti-apoptosis activity in virus infected tissue culture cells. Journal of Virological Methods. 118: 9-13
Mott KR, Osorio N, Jin L, et al. (2003) The bovine herpesvirus-1 LR ORF2 is critical for this gene's ability to restore the high wild-type reactivation phenotype to a herpes simplex virus-1 LAT null mutant. The Journal of General Virology. 84: 2975-85
Jin L, Peng W, Perng GC, et al. (2003) Identification of herpes simplex virus type 1 latency-associated transcript sequences that both inhibit apoptosis and enhance the spontaneous reactivation phenotype. Journal of Virology. 77: 6556-61
Brick DJ, Burke RD, Minkley AA, et al. (2000) Ectromelia virus virulence factor p28 acts upstream of caspase-3 in response to UV light-induced apoptosis. The Journal of General Virology. 81: 1087-97
Brick DJ, Burke RD, Schiff L, et al. (1998) Shope fibroma virus RING finger protein N1R binds DNA and inhibits apoptosis. Virology. 249: 42-51
Dickstein R, Davies PC, Hoogland DS, et al. (1998) An Arabidopsis lipase-like gene within a sequence previously characterized as an intron Journal of Biochemistry, Molecular Biology and Biophysics. 1: 265-273
Brick DJ, Brumlik MJ, Buckley JT, et al. (1995) A new family of lipolytic plant enzymes with members in rice, arabidopsis and maize. Febs Letters. 377: 475-80
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