Mark E. Gurney

Affiliations: 
deCode Genetics Inc 
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"Mark Gurney"
Mean distance: 13.07 (cluster 17)
 
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Publications

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Gurney ME, D'Amato EC, Burgin AB. (2015) Phosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 12: 49-56
Hagen TJ, Mo X, Burgin AB, et al. (2014) Discovery of triazines as selective PDE4B versus PDE4D inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 4031-4
Butchbach ME, Singh J, Gurney ME, et al. (2014) The effect of diet on the protective action of D156844 observed in spinal muscular atrophy mice. Experimental Neurology. 256: 1-6
Fox D, Burgin AB, Gurney ME. (2014) Structural basis for the design of selective phosphodiesterase 4B inhibitors. Cellular Signalling. 26: 657-63
Tilly P, Charles AL, Ludwig S, et al. (2014) Blocking the EP3 receptor for PGE2 with DG-041 decreases thrombosis without impairing haemostatic competence. Cardiovascular Research. 101: 482-91
Gurney ME, Burgin AB, Magnusson OT, et al. (2011) Small molecule allosteric modulators of phosphodiesterase 4. Handbook of Experimental Pharmacology. 167-92
Sandanayaka V, Mamat B, Bhagat N, et al. (2010) Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds Bioorganic and Medicinal Chemistry Letters. 20: 2851-2854
Zhou N, Polozov AM, O'Connell M, et al. (2010) 1,7-Disubstituted oxyindoles are potent and selective EP(3) receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 20: 2658-64
Fabre JE, Gurney ME. (2010) Limitations of current therapies to prevent thrombosis: a need for novel strategies. Molecular Biosystems. 6: 305-15
Burgin AB, Magnusson OT, Singh J, et al. (2010) Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nature Biotechnology. 28: 63-70
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