Benjamin T. Circello, Ph.D.

Affiliations: 
2010 University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
Area:
Microbiology Biology
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"Benjamin Circello"

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William W. Metcalf grad student 2010 UIUC
 (Investigations into the biosynthesis and mode of action of the phosphonate antibiotic dehydrophos.)
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Publications

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Yu X, Doroghazi JR, Janga SC, et al. (2013) Diversity and abundance of phosphonate biosynthetic genes in nature. Proceedings of the National Academy of Sciences of the United States of America. 110: 20759-64
Metcalf WW, Griffin BM, Cicchillo RM, et al. (2012) Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean. Science (New York, N.Y.). 337: 1104-7
Circello BT, Miller CG, Lee JH, et al. (2011) The antibiotic dehydrophos is converted to a toxic pyruvate analog by peptide bond cleavage in Salmonella enterica Antimicrobial Agents and Chemotherapy. 55: 3357-3362
Lee JH, Bae B, Kuemin M, et al. (2010) Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis Proceedings of the National Academy of Sciences of the United States of America. 107: 17557-17562
Circello BT, Eliot AC, Lee JH, et al. (2010) Molecular Cloning and Heterologous Expression of the Dehydrophos Biosynthetic Gene Cluster Chemistry and Biology. 17: 402-411
Borisova SA, Circello BT, Zhang JK, et al. (2010) Biosynthesis of Rhizocticins, Antifungal Phosphonate Oligopeptides Produced by Bacillus subtilis ATCC6633 Chemistry and Biology. 17: 28-37
Shao Z, Blodgett JA, Circello BT, et al. (2008) Biosynthesis of 2-hydroxyethylphosphonate, an unexpected intermediate common to multiple phosphonate biosynthetic pathways. The Journal of Biological Chemistry. 283: 23161-8
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