Christopher D. Hupp, Ph.D.

Affiliations: 
2009 Michigan State University, East Lansing, MI 
Area:
Organic Chemistry
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"Christopher Hupp"
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Jetze J. Tepe grad student 2009 Michigan State
 (Accessing the 2-amino-5,5-disubstituted-1H-imidazol-4-one scaffold for natural product synthesis and evaluation for checkpoint kinase 2 inhibition.)
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Publications

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McCort G, Arrebola R, Calvet L, et al. (2019) Abstract 3070: Discovery of novel potent allele-selective KRAS-G12C covalent inhibitors stemming from DNA-encoded library Cancer Research. 79: 3070-3070
Cuozzo JW, Centrella PA, Gikunju D, et al. (2017) Discovery of a potent BTK inhibitor with a novel binding mode using parallel selections with a DNA-encoded chemical library. Chembiochem : a European Journal of Chemical Biology
Hewlett NM, Hupp CD, Tepe JJ. (2010) ChemInform Abstract: Reactivity of Oxazol-5-(4H)-ones and Their Application Toward Natural Product Synthesis. Cheminform. 41
Hupp CD, Tepe JJ. (2009) 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride-mediated oxazole rearrangement: gaining access to a unique marine alkaloid scaffold. The Journal of Organic Chemistry. 74: 3406-13
Kahlon DK, Lansdell TA, Fisk JS, et al. (2009) Nuclear factor-κB mediated inhibition of cytokine production by imidazoline scaffolds Journal of Medicinal Chemistry. 52: 1302-1309
Hewlett NM, Hupp CD, Tepe JJ. (2009) Reactivity of oxazol-5-(4H)-ones and their application toward natural product synthesis Synthesis. 2825-2839
Hupp CD, Tepe JJ. (2008) Total synthesis of a marine alkaloid from the tunicate Dendrodoa grossularia. Organic Letters. 10: 3737-9
Sharma V, Hupp CD, Tepe JJ. (2007) Enhancement of chemotherapeutic efficacy by small molecule inhibition of NF-kappaB and checkpoint kinases. Current Medicinal Chemistry. 14: 1061-74
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