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Adam S. Brank, Ph.D.

Affiliations: 
2000 University of Nebraska Medical Center, Omaha, NE, United States 
Area:
Biochemistry, Molecular Biology, Oncology
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Judith K. Christman grad student 2000 University of Nebraska Medical Center
 (Development and characterization of DNA methyltransferase inhibitors.)

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van Bemmel DM, Brank AS, Eritja R, et al. (2009) DNA (Cytosine-C5) methyltransferase inhibition by oligodeoxyribonucleotides containing 2-(1H)-pyrimidinone (zebularine aglycon) at the enzymatic target site. Biochemical Pharmacology. 78: 633-41
Brank AS, Eritja R, Garcia RG, et al. (2002) Inhibition of HhaI DNA (Cytosine-C5) methyltransferase by oligodeoxyribonucleotides containing 5-aza-2'-deoxycytidine: examination of the intertwined roles of co-factor, target, transition state structure and enzyme conformation. Journal of Molecular Biology. 323: 53-67
Brank AS, Van Bemmel DM, Christman JK. (2002) Optimization of baculovirus-mediated expression and purification of hexahistidine-tagged murine DNA (cytosine-C5)-methyltransferase-1 in Spodoptera frugiperda 9 cells. Protein Expression and Purification. 25: 31-40
Güimil García R, Brank AS, Christman JK, et al. (2001) Synthesis of oligonucleotide inhibitors of DNA (Cytosine-C5) methyltransferase containing 5-azacytosine residues at specific sites. Antisense & Nucleic Acid Drug Development. 11: 369-78
Wang P, Brank AS, Banavali NK, et al. (2000) Use of oligodeoxyribonucleotides with conformationally constrained abasic sugar targets to probe the mechanism of base flipping by hhaI DNA (cytosine C5)-methyltransferase Journal of the American Chemical Society. 122: 12422-12434
Sheikhnejad G, Brank A, Christman JK, et al. (1999) Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine. Journal of Molecular Biology. 285: 2021-34
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