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Junji Chen, Ph.D.

Affiliations: 
2001 University of New Hampshire, Durham, NH, United States 
Area:
Molecular Biology, Genetics
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"Junji Chen"
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Clyde L. Denis grad student 2001 UNH
 (The enzymatic function of the CCR4 protein.)

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Publications

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Viswanathan P, Ohn T, Chiang YC, et al. (2004) Mouse CAF1 can function as a processive deadenylase/3'-5'-exonuclease in vitro but in yeast the deadenylase function of CAF1 is not required for mRNA poly(A) removal. The Journal of Biological Chemistry. 279: 23988-95
Clark LB, Viswanathan P, Quigley G, et al. (2004) Systematic mutagenesis of the leucine-rich repeat (LRR) domain of CCR4 reveals specific sites for binding to CAF1 and a separate critical role for the LRR in CCR4 deadenylase activity. The Journal of Biological Chemistry. 279: 13616-23
Denis CL, Chen J. (2003) The CCR4-NOT complex plays diverse roles in mRNA metabolism. Progress in Nucleic Acid Research and Molecular Biology. 73: 221-50
Viswanathan P, Chen J, Chiang YC, et al. (2003) Identification of multiple RNA features that influence CCR4 deadenylation activity. The Journal of Biological Chemistry. 278: 14949-55
Denis CL, Chen J. (2003) The CCR4-NOT Complex Plays Diverse Roles in mRNA Metabolism Progress in Nucleic Acid Research and Molecular Biology. 73: 221-250
Chen J, Chiang YC, Denis CL. (2002) CCR4, a 3'-5' poly(A) RNA and ssDNA exonuclease, is the catalytic component of the cytoplasmic deadenylase. The Embo Journal. 21: 1414-26
Chen J, Rappsilber J, Chiang YC, et al. (2001) Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex. Journal of Molecular Biology. 314: 683-94
Denis CL, Chiang YC, Cui Y, et al. (2001) Genetic evidence supports a role for the yeast CCR4-NOT complex in transcriptional elongation. Genetics. 158: 627-34
Tucker M, Valencia-Sanchez MA, Staples RR, et al. (2001) The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae. Cell. 104: 377-86
Liu HY, Chiang YC, Pan J, et al. (2001) Characterization of CAF4 and CAF16 reveals a functional connection between the CCR4-NOT complex and a subset of SRB proteins of the RNA polymerase II holoenzyme. The Journal of Biological Chemistry. 276: 7541-8
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