Joseph R. Mazzulli, Ph.D.
Affiliations: | 2007 | University of Pennsylvania, Philadelphia, PA, United States |
Area:
Neuroscience BiologyGoogle:
"Joseph Mazzulli"Mean distance: (not calculated yet)
Cross-listing: Physics Tree
Parents
Sign in to add mentor| Harry Ischiropoulos | grad student | 2007 | Penn | |
| (Catechol oxidation and alpha-synuclein aggregation: Implications for selective dopaminergic neurodegeneration in Parkinson's disease.) | ||||
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Publications
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| Fagen SJ, Burgess JD, Lim MJ, et al. (2023) Honokiol decreases alpha-synuclein mRNA levels and reveals novel targets for modulating alpha-synuclein expression. Frontiers in Aging Neuroscience. 15: 1179086 |
| Drobny A, Boros FA, Balta D, et al. (2023) Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models. Translational Neurodegeneration. 12: 31 |
| Pitcairn C, Murata N, Zalon A, et al. (2023) Impaired autophagic-lysosomal fusion in Parkinson's patient midbrain neurons occurs through loss of ykt6 and is rescued by farnesyltransferase inhibition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience |
| Prieto Huarcaya S, Drobny A, Marques ARA, et al. (2022) Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models. Autophagy |
| Francelle L, Mazzulli JR. (2022) Neuroinflammation in Gaucher disease, neuronal ceroid lipofuscinosis, and commonalities with Parkinson's disease. Brain Research. 1780: 147798 |
| Fredriksen K, Aivazidis S, Sharma K, et al. (2021) Pathological α-syn aggregation is mediated by glycosphingolipid chain length and the physiological state of α-syn in vivo. Proceedings of the National Academy of Sciences of the United States of America. 118 |
| Stojkovska I, Wani WY, Zunke F, et al. (2021) Rescue of α-synuclein aggregation in Parkinson's patient neurons by synergistic enhancement of ER proteostasis and protein trafficking. Neuron |
| Stojkovska I, Mazzulli JR. (2021) Detection of pathological alpha-synuclein aggregates in human iPSC-derived neurons and tissue. Star Protocols. 2: 100372 |
| Cuddy LK, Wani WY, Morella ML, et al. (2019) Stress-Induced Cellular Clearance Is Mediated by the SNARE Protein ykt6 and Disrupted by α-Synuclein. Neuron |
| Tsunemi T, Perez-Rosello T, Ishiguro Y, et al. (2019) Increased lysosomal exocytosis induced by lysosomal Ca channel agonists protects human dopaminergic neurons from α-synuclein toxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience |