Dongbiao Shen, Ph.D.
Affiliations: | 2012 | University of Michigan, Ann Arbor, Ann Arbor, MI |
Area:
Neurobiology Biology, Cell Biology, Physiology BiologyGoogle:
"Dongbiao Shen"Mean distance: 17.55 (cluster 11) | S | N | B | C | P |
Parents
Sign in to add mentor| Haoxing Xu | grad student | 2012 | University of Michigan | |
| (Regulation of TRPML1 by lipids in lysosomes.) | ||||
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Publications
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| Wang X, Zhang X, Dong XP, et al. (2012) TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell. 151: 372-83 |
| Yu T, Chung C, Shen D, et al. (2012) Ryanodine receptor antagonists adapt NPC1 proteostasis to ameliorate lipid storage in Niemann-Pick type C disease fibroblasts. Human Molecular Genetics. 21: 3205-14 |
| Shen D, Wang X, Li X, et al. (2012) Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release. Nature Communications. 3: 731 |
| Wang X, Zhang X, Dong X, et al. (2012) Novel Na+-Selective Channels in the Lysosome Biophysical Journal. 102: 105a |
| Shen D, Wang X, Xu H. (2011) Pairing phosphoinositides with calcium ions in endolysosomal dynamics: phosphoinositides control the direction and specificity of membrane trafficking by regulating the activity of calcium channels in the endolysosomes. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 33: 448-57 |
| Dong XP, Shen D, Wang X, et al. (2010) PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome. Nature Communications. 1: 38 |
| Cheng X, Jin J, Hu L, et al. (2010) TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell. 141: 331-43 |
| Cheng X, Shen D, Samie M, et al. (2010) Mucolipins: Intracellular TRPML1-3 channels. Febs Letters. 584: 2013-21 |
| Wang X, Dong X, Shen D, et al. (2010) Activating Mutations Reveal a Role of TRPML1 in Lysosomal Exocytosis Biophysical Journal. 98 |
| Dong XP, Wang X, Shen D, et al. (2009) Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis. The Journal of Biological Chemistry. 284: 32040-52 |