Brian D. Klein, Ph.D.

Affiliations: 
2003 University of Utah, Salt Lake City, UT 
Area:
Neuroscience Biology, Pharmacology, Audiology, Genetics
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H. Steve White grad student 2003 University of Utah
 (Pathophysiology associated with a single gene (MASS1) mutation underlying the robust audiogenic seizure phenotype in Frings mice.)
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Publications

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Metcalf CS, Klein BD, Smith MD, et al. (2018) Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2-positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model. Epilepsia
Klein BD, Jacobson CA, Metcalf CS, et al. (2017) Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP). Neurochemical Research
Metcalf CS, Smith MD, Klein BD, et al. (2017) Preclinical Analgesic and Safety Evaluation of the GalR2-preferring Analog, NAX 810-2. Neurochemical Research
Metcalf CS, Klein BD, Smith MD, et al. (2017) Efficacy of mGlu2 -positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures. Epilepsia
Metcalf CS, Klein BD, McDougle DR, et al. (2017) Preclinical evaluation of intravenous NAX 810-2, a novel GalR2-preferring analog, for anticonvulsant efficacy and pharmacokinetics. Epilepsia
Metcalf CS, Klein BD, McDougle DR, et al. (2015) Analgesic properties of a peripherally acting and GalR2 receptor-preferring galanin analog in inflammatory, neuropathic, and acute pain models. The Journal of Pharmacology and Experimental Therapeutics. 352: 185-93
Jequier Gygax M, Klein BD, White HS, et al. (2014) Efficacy and tolerability of the galanin analog NAX 5055 in the multiple-hit rat model of symptomatic infantile spasms. Epilepsy Research. 108: 98-108
McComsey DF, Smith-Swintosky VL, Parker MH, et al. (2013) Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112). Journal of Medicinal Chemistry. 56: 9019-30
Zhang L, Klein BD, Metcalf CS, et al. (2013) Incorporation of monodisperse oligoethyleneglycol amino acids into anticonvulsant analogues of galanin and neuropeptide y provides peripherally acting analgesics. Molecular Pharmaceutics. 10: 574-85
Green BR, Klein BD, Lee HK, et al. (2013) Cyclic analogs of galanin and neuropeptide Y by hydrocarbon stapling. Bioorganic & Medicinal Chemistry. 21: 303-10
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