Xinmin (Simon) Xie, M.D., Ph.D.
Affiliations: | AfaSci Research Laboratory, Burlingame, CA, United States |
Area:
Technology development for automation of rodent behavioral assay, ion channel and neuropeptide pharmacologyWebsite:
http://www.afasci.comGoogle:
"Xinmin Xie or Xinmin Simon Xie"Bio:
Xinmin (Simon) Xie, B.S. in medicine (Sun Yet-Sen University of Medical Sciences, Guangzhou, China 1982), M.D. (University of Bern, Switzerland 1989), and Ph.D. (University of London, UK 1992) is the founder of AfaSci, Inc. California, which specializes in developing automation devices for neurobehavioral phenotyping and drug efficacy and toxicity screens in vivo. Dr. Xie also serves as a Consulting Associate Professor at Stanford University School of Medicine.
Dr. Xie as the Principal Investigator has rich experience in directing and executing NIH-sponsored research including R01, R03 R21, and multiple R43, R44 SBIR/STTR grants. Recently he established the AfaSci Research laboratory and leads a team investigating roles of hypocretin/orexin in modulation of stress and pain, and on the development of dissolvable microneedles to deliver drugs for the treatment of neurogenic inflammatory pain.
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Mean distance: 16.92 (cluster 11)
Publications
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| Xie X, Crowder TL, Yamanaka A, et al. (2006) GABA(B) receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus. The Journal of Physiology. 574: 399-414 |
| Thomas P, Sundaram H, Krishek BJ, et al. (1997) Regulation of neuronal and recombinant GABA(A) receptor ion channels by xenovulene A, a natural product isolated from Acremonium strictum. The Journal of Pharmacology and Experimental Therapeutics. 282: 513-20 |
| Krishek BJ, Xie X, Blackstone C, et al. (1994) Regulation of GABAA receptor function by protein kinase C phosphorylation. Neuron. 12: 1081-95 |
| Xie X, Smart TG. (1994) Modulation of long-term potentiation in rat hippocampal pyramidal neurons by zinc. Pflã¼Gers Archiv : European Journal of Physiology. 427: 481-6 |
| Xie X, Hider RC, Smart TG. (1994) Modulation of GABA-mediated synaptic transmission by endogenous zinc in the immature rat hippocampus in vitro. The Journal of Physiology. 478: 75-86 |
| Krishek BJ, Xie X, Bouchet MJ, et al. (1994) m-sulphonate benzene diazonium chloride: a novel GABAA receptor antagonist. Neuropharmacology. 33: 1125-30 |
| Smart TG, Xie X, Krishek BJ. (1994) Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc. Progress in Neurobiology. 42: 393-441 |
| Xie X, Smart TG. (1993) Properties of GABA-mediated synaptic potentials induced by zinc in adult rat hippocampal pyramidal neurones. The Journal of Physiology. 460: 503-23 |
| Xie X, Gerber U, Gähwiler BH, et al. (1993) Interaction of zinc with ionotropic and metabotropic glutamate receptors in rat hippocampal slices. Neuroscience Letters. 159: 46-50 |
| Xie X, Smart TG. (1993) Giant GABAB-mediated synaptic potentials induced by zinc in the rat hippocampus: paradoxical effects of zinc on the GABAB receptor. The European Journal of Neuroscience. 5: 430-6 |