Xinmin (Simon) Xie, M.D., Ph.D.

AfaSci Research Laboratory, Burlingame, CA, United States 
Technology development for automation of rodent behavioral assay, ion channel and neuropeptide pharmacology
"Xinmin Xie or Xinmin Simon Xie"

Xinmin (Simon) Xie, B.S. in medicine (Sun Yet-Sen University of Medical Sciences, Guangzhou, China 1982), M.D. (University of Bern, Switzerland 1989), and Ph.D. (University of London, UK 1992) is the founder of AfaSci, Inc. California, which specializes in developing automation devices for neurobehavioral phenotyping and drug efficacy and toxicity screens in vivo. Dr. Xie also serves as a Consulting Associate Professor at Stanford University School of Medicine.

Dr. Xie as the Principal Investigator has rich experience in directing and executing NIH-sponsored research including R01, R03 R21, and multiple R43, R44 SBIR/STTR grants. Recently he established the AfaSci Research laboratory and leads a team investigating roles of hypocretin/orexin in modulation of stress and pain, and on the development of dissolvable microneedles to deliver drugs for the treatment of neurogenic inflammatory pain.

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Mean distance: 16.92 (cluster 11)
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Khroyan TV, Zhang J, Yang L, et al. (2012) Rodent motor and neuropsychological behaviour measured in home cages using the integrated modular platform SmartCageâ„¢. Clinical and Experimental Pharmacology & Physiology. 39: 614-22
Hara J, Gerashchenko D, Wisor JP, et al. (2009) Thyrotropin-releasing hormone increases behavioral arousal through modulation of hypocretin/orexin neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 3705-14
Sonmez K, Zaveri NT, Kerman IA, et al. (2009) Evolutionary sequence modeling for discovery of peptide hormones. Plos Computational Biology. 5: e1000258
Xie X, Wisor JP, Hara J, et al. (2008) Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia. The Journal of Clinical Investigation. 118: 2471-81
Flores AE, Flores JE, Deshpande H, et al. (2007) Pattern recognition of sleep in rodents using piezoelectric signals generated by gross body movements. Ieee Transactions On Bio-Medical Engineering. 54: 225-33
Xie X, Crowder TL, Yamanaka A, et al. (2006) GABA(B) receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus. The Journal of Physiology. 574: 399-414
Xie X, Dumas T, Tang L, et al. (2005) Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice. Brain Research. 1052: 212-21
Ruby NF, Brennan TJ, Xie X, et al. (2002) Role of melanopsin in circadian responses to light. Science (New York, N.Y.). 298: 2211-3
Thomas P, Sundaram H, Krishek BJ, et al. (1997) Regulation of neuronal and recombinant GABA(A) receptor ion channels by xenovulene A, a natural product isolated from Acremonium strictum. The Journal of Pharmacology and Experimental Therapeutics. 282: 513-20
Krishek BJ, Xie X, Blackstone C, et al. (1994) Regulation of GABAA receptor function by protein kinase C phosphorylation. Neuron. 12: 1081-95
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