George G. Brownlee, Ph.D.
Affiliations: | Pathology | University of Oxford, Oxford, United Kingdom |
Area:
first cloned and patented the production and clinical use of recombinant human blood clotting factor IXWebsite:
http://en.wikipedia.org/wiki/Sir_William_Dunn_School_of_PathologyGoogle:
"George Brownlee"Bio:
http://www.ox.ac.uk/admissions/postgraduate_courses/course_guide/pathology.html
Mean distance: 15.84 (cluster 18) | S | N | B | C | P |
Parents
Sign in to add mentor| Frederick Sanger | grad student | 1963-1966 | Oxford (Chemistry Tree) | |
| (deduced from http://www.filmandsound.ac.uk/collections/records/0028-0000-2584-0000-0-0000-0000-0.html) | ||||
Children
Sign in to add trainee| Nicholas Proudfoot | grad student | MRC-LMB (Chemistry Tree) | |
| Stanley Fields | grad student | 1981 | MRC-LMB (Microtree) |
| Gregory Paul Winter | post-doc | 1976-1980 | MRC-LMB |
| KH Andy Choo | post-doc | 1982-1984 |
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Publications
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| Brownlee GG. (2018) The (chain) terminators. Nature Reviews. Molecular Cell Biology |
| Brownlee GG. (2015) Frederick Sanger CBE CH OM. 13 August 1918 — 19 November 2013 Biographical Memoirs of Fellows of the Royal Society. 61: 437-466 |
| Brownlee GG. (2013) Frederick Sanger (1918-2013). Current Biology : Cb. 23: R1074-6 |
| Gabriel G, Klingel K, Otte A, et al. (2011) Differential use of importin-α isoforms governs cell tropism and host adaptation of influenza virus. Nature Communications. 2: 156 |
| Leung BW, Chen H, Brownlee GG. (2010) Correlation between polymerase activity and pathogenicity in two duck H5N1 influenza viruses suggests that the polymerase contributes to pathogenicity. Virology. 401: 96-106 |
| Dreger M, Leung BW, Brownlee GG, et al. (2009) A quantitative strategy to detect changes in accessibility of protein regions to chemical modification on heterodimerization. Protein Science : a Publication of the Protein Society. 18: 1448-58 |
| Kashiwagi T, Leung BW, Deng T, et al. (2009) The N-terminal region of the PA subunit of the RNA polymerase of influenza A/HongKong/156/97 (H5N1) influences promoter binding. Plos One. 4: e5473 |
| Vreede FT, Gifford H, Brownlee GG. (2008) Role of initiating nucleoside triphosphate concentrations in the regulation of influenza virus replication and transcription. Journal of Virology. 82: 6902-10 |
| Maier HJ, Kashiwagi T, Hara K, et al. (2008) Differential role of the influenza A virus polymerase PA subunit for vRNA and cRNA promoter binding. Virology. 370: 194-204 |
| Vreede FT, Brownlee GG. (2007) Influenza virion-derived viral ribonucleoproteins synthesize both mRNA and cRNA in vitro. Journal of Virology. 81: 2196-204 |