John N. Mariani, Ph.D.
Affiliations: | 2009-2016 | Neuroscience, Neurology | Icahn School of Medicine at Mount Sinai, New York, NY, United States |
| 2016- | Neurology, Center for Translational Neuromedicine | University of Rochester, Rochester, NY |
Area:
Synaptogenesis, Synaptic Plasticity, Astrocytes, MS, Oligodendrocytes, Glia, Blood Brain Barrier, Endothelial Cells, Bioinformatics, SequencingGoogle:
"John Mariani"Mean distance: 20.49 (cluster 32) | S | N | B | C | P |
Parents
Sign in to add mentor| Stephen L. Boehm | research assistant | 2007-2009 | Binghamton University |
| Deanna L. Benson | research assistant | 2009-2010 | Mount Sinai School of Medicine |
| Gareth R. John | grad student | 2011-2016 | Mount Sinai School of Medicine |
| Steven A. Goldman | post-doc | 2016- | Rochester |
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Publications
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| Mariani JN, Mansky B, Madsen PM, et al. (2024) Repression of developmental transcription factor networks triggers aging-associated gene expression in human glial progenitor cells. Nature Communications. 15: 3873 |
| Takasugi M, Ohtani N, Takemura K, et al. (2023) CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance. Cell Reports. 42: 113130 |
| Vieira R, Mariani JN, Huynh NPT, et al. (2023) Young glial progenitor cells competitively replace aged and diseased human glia in the adult chimeric mouse brain. Nature Biotechnology |
| Osorio MJ, Mariani JN, Zou L, et al. (2022) Glial progenitor cells of the adult human white and grey matter are contextually distinct. Glia |
| Benraiss A, Mariani JN, Tate A, et al. (2022) A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice. Cell Reports. 40: 111291 |
| Benraiss A, Mariani JN, Osipovitch M, et al. (2021) Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease. Cell Reports. 36: 109308 |
| Goldman SA, Mariani JN, Madsen PM. (2021) Glial progenitor cell-based repair of the dysmyelinated brain: Progression to the clinic. Seminars in Cell & Developmental Biology |
| Windrem MS, Schanz SJ, Zou L, et al. (2020) Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain. Cell Reports. 31: 107658 |
| Mariani JN, Zou L, Goldman SA. (2019) Human Glial Chimeric Mice to Define the Role of Glial Pathology in Human Disease. Methods in Molecular Biology (Clifton, N.J.). 1936: 311-331 |
| Osipovitch M, Asenjo Martinez A, Mariani JN, et al. (2019) Human ESC-Derived Chimeric Mouse Models of Huntington's Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation. Cell Stem Cell. 24: 107-122.e7 |