Darrell A. Henze

Affiliations: 
Pain & Migraine Research Merck Research Laboratories, Boston, MA, United States 
Area:
Neuroscience, Pain, TrkA, cannabinoids, sodium channels
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"Darrell Henze"
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Publications

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Ballard JE, Pall PS, Vardigan J, et al. (2021) Translational Pharmacokinetic-Pharmacodynamic Modeling of NaV1.7 Inhibitor MK-2075 to Inform Human Efficacious Dose. Frontiers in Pharmacology. 12: 786078
Adams GL, Pall PS, Grauer SM, et al. (2021) Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Na1.7 for the Treatment of Pain. Journal of Medicinal Chemistry
Lange HS, Vardigan JD, Cannon CE, et al. (2021) Effects of a novel M4 muscarinic positive allosteric modulator on behavior and cognitive deficits relevant to Alzheimer's disease and schizophrenia in rhesus monkey. Neuropharmacology. 108754
Kraus RL, Zhao F, Pall PS, et al. (2021) Na1.7 target modulation and efficacy can be measured in nonhuman primate assays. Science Translational Medicine. 13
Ballard JE, Pall P, Vardigan J, et al. (2020) Application of Pharmacokinetic-Pharmacodynamic Modeling to Inform Translation of In Vitro NaV1.7 Inhibition to In Vivo Pharmacological Response in Non-human Primate. Pharmaceutical Research. 37: 181
Grauer SM, Sanoja R, Poulin D, et al. (2020) Antinociceptive Effects of Potent, Selective and Brain Penetrant Muscarinic M Positive Allosteric Modulators in Rodent Pain Models. Brain Research. 146814
Vardigan JD, Houghton AK, Lange HS, et al. (2018) Pharmacological validation of a novel nonhuman primate measure of thermal responsivity with utility for predicting analgesic effects. Journal of Pain Research. 11: 735-741
Pero JE, Rossi MA, Lehman HDGF, et al. (2017) Benzoxazolinone aryl sulfonamides as potent, selective Nav1.7 inhibitors with in vivo efficacy in a preclinical pain model. Bioorganic & Medicinal Chemistry Letters
Hurzy DM, Henze DA, Cabalu TD, et al. (2017) Design, synthesis and SAR of substituted indoles as selective TrkA inhibitors. Bioorganic & Medicinal Chemistry Letters
Price EA, Krasowska-Zoladek A, Nanda KK, et al. (2017) Development of a pharmacodynamic biomarker to measure target engagement from inhibition of the NGF-TrkA pathway. Journal of Neuroscience Methods
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