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Joshua J. Ziarek, Ph.D.

Affiliations: 
2017-2023 Biochemistry Indiana University, Bloomington, Bloomington, IN, United States 
 2023- Pharmacology Northwestern University Feinberg School of Medicine, Chicago, IL, United States 
Area:
biochemistry, protein chemistry, NMR, structural biology, conformational dynamics
Website:
http://www.ziareklab.com
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"Joshua Ziarek"
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Parents

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J Rudi Strickler research assistant 2004-2007 UW-Milwaukee (Microtree)
Brian F. Volkman grad student 2011 Medical College of Wisconsin
 (Biophysical analysis of CXCL12/CXCR4 interactions and structure-guided inhibitor discovery.)
Gerhard Wagner post-doc Harvard Medical School
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Publications

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Bumbak F, Bower JB, Zemmer SC, et al. (2023) Stabilization of pre-existing neurotensin receptor conformational states by β-arrestin-1 and the biased allosteric modulator ML314. Nature Communications. 14: 3328
Kahraman K, Robson SA, Göcenler O, et al. (2023) Characterizing the monomer-dimer equilibrium of UbcH8/Ube2L6: A combined SAXS and NMR study. Biorxiv : the Preprint Server For Biology
Bumbak F, Pons M, Inoue A, et al. (2023) Ligands selectively tune the local and global motions of neurotensin receptor 1 (NTS). Cell Reports. 42: 112015
Dixon AD, Inoue A, Robson SA, et al. (2022) Effect of Ligands and Transducers on the Neurotensin Receptor 1 Conformational Ensemble. Journal of the American Chemical Society
Robson SA, Dağ Ç, Wu H, et al. (2021) TRACT revisited: an algebraic solution for determining overall rotational correlation times from cross-correlated relaxation rates. Journal of Biomolecular Nmr
Hitchinson B, Eby JM, Gao X, et al. (2018) Biased antagonism of CXCR4 avoids antagonist tolerance. Science Signaling. 11
Gruenhagen T, Ziarek JJ, Schlebach JP. (2018) Bicelle Size Modulates the Rate of Bacteriorhodopsin Folding. Protein Science : a Publication of the Protein Society
Chhabra S, Fischer P, Takeuchi K, et al. (2018) N detection harnesses the slow relaxation property of nitrogen: Delivering enhanced resolution for intrinsically disordered proteins. Proceedings of the National Academy of Sciences of the United States of America
Ziarek JJ, Baptista D, Wagner G. (2017) Recent developments in solution nuclear magnetic resonance (NMR)-based molecular biology. Journal of Molecular Medicine (Berlin, Germany)
Ziarek JJ, Kleist AB, London N, et al. (2017) Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation. Science Signaling. 10
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