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David McKinzie, Ph.D.

Affiliations: 
Neuroscience Eli Lilly, Indianapolis, IN, United States 
Area:
addiction
Website:
http://www.iupui.edu/~medneuro/FacultyPages/mckinzie.htm
Google:
"David McKinzie"
Mean distance: 16.27 (cluster 19)
 
SNBCP
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Publications

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Monn JA, Prieto L, Taboada L, et al. (2015) Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-Substituted-2-Aminobicyclo[3.1.0]hexane-2,6-Dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist. Journal of Medicinal Chemistry
Liu B, Croy CH, Hitchcock SA, et al. (2015) Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M1 agonists. Bioorganic & Medicinal Chemistry Letters
Kinon BJ, Millen BA, Zhang L, et al. (2015) Exploratory Analysis for a Targeted Patient Population Responsive to the Metabotropic Glutamate 2/3 Receptor Agonist Pomaglumetad Methionil in Schizophrenia. Biological Psychiatry
Monn JA, Prieto L, Taboada L, et al. (2015) Synthesis and pharmacological characterization of C4-disubstituted analogs of 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: identification of a potent, selective metabotropic glutamate receptor agonist and determination of agonist-bound human mGlu2 and mGlu3 amino terminal domain structures. Journal of Medicinal Chemistry. 58: 1776-94
Rorick-Kehn LM, Witcher JW, Lowe SL, et al. (2014) Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 18
Toledo MA, Pedregal C, Lafuente C, et al. (2014) Discovery of a novel series of orally active nociceptin/orphanin FQ (NOP) receptor antagonists based on a dihydrospiro(piperidine-4,7'-thieno[2,3-c]pyran) scaffold. Journal of Medicinal Chemistry. 57: 3418-29
Rorick-Kehn LM, Witkin JM, Statnick MA, et al. (2014) LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders. Neuropharmacology. 77: 131-44
Watt ML, Rorick-Kehn L, Shaw DB, et al. (2013) The muscarinic acetylcholine receptor agonist BuTAC mediates antipsychotic-like effects via the M4 subtype. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 2717-26
Monn JA, Valli MJ, Massey SM, et al. (2013) Synthesis and pharmacological characterization of 4-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: identification of new potent and selective metabotropic glutamate 2/3 receptor agonists. Journal of Medicinal Chemistry. 56: 4442-55
Hao J, Dehlinger V, Fivush AM, et al. (2013) Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator. Bioorganic & Medicinal Chemistry Letters. 23: 1249-52
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