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Richard B. Westkaemper

Affiliations: 
Virginia Commonwealth University, Richmond, VA, United States 
Area:
Pharmaceutical Chemistry, Pharmacology, Organic Chemistry
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"Richard Westkaemper"
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Donna L. McGovern grad student 2009 VCU

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Vardy E, Sassano MF, Rennekamp AJ, et al. (2015) Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides. Chemistry & Biology. 22: 764-75
Vardy E, Mosier PD, Frankowski KJ, et al. (2013) Chemotype-selective modes of action of κ-opioid receptor agonists. The Journal of Biological Chemistry. 288: 34470-83
Elbegdorj O, Westkaemper RB, Zhang Y. (2013) A homology modeling study toward the understanding of three-dimensional structure and putative pharmacological profile of the G-protein coupled receptor GPR55. Journal of Molecular Graphics & Modelling. 39: 50-60
Wu H, Wacker D, Mileni M, et al. (2012) Structure of the human κ-opioid receptor in complex with JDTic. Nature. 485: 327-32
McGovern DL, Mosier PD, Roth BL, et al. (2010) CoMFA analyses of C-2 position salvinorin A analogs at the kappa-opioid receptor provides insights into epimer selectivity. Journal of Molecular Graphics & Modelling. 28: 612-25
Shah JR, Mosier PD, Peddi S, et al. (2010) 9-Aminomethyl-9,10-dihydroanthracene (AMDA) analogs as structural probes for steric tolerance in 5-HT2A and H1 receptor binding sites. Bioorganic & Medicinal Chemistry Letters. 20: 935-8
Shah JR, Mosier PD, Roth BL, et al. (2009) Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity. Bioorganic & Medicinal Chemistry. 17: 6496-504
Yan F, Bikbulatov RV, Mocanu V, et al. (2009) Structure-based design, synthesis, and biochemical and pharmacological characterization of novel salvinorin A analogues as active state probes of the kappa-opioid receptor. Biochemistry. 48: 6898-908
Li G, Aschenbach LC, Chen J, et al. (2009) Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists. Journal of Medicinal Chemistry. 52: 1416-27
Li G, Aschenbach LC, Chen J, et al. (2009) Corrections to design, synthesis, and biological evaluation of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives as μ opioid receptor selective antagonists (Journal of Medicinal Chemistry (2009) 52, (1416) DOI 10.1021/jm801272c) Journal of Medicinal Chemistry. 52: 8057
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