Malcolm J. Low, M.D., Ph.D
Affiliations: | Oregon Health and Science University, Portland, OR | ||
| Molecular & Integrative Physiology and Metabolism, Endocrinology & Diabetes | University of Michigan, Ann Arbor, Ann Arbor, MI |
Area:
obesity, diabetes, hypothalamusWebsite:
https://www.umms.med.umich.edu/pibsfacsearch/facultyPage.do?facUniqname=mjlowGoogle:
"Malcolm Low"Mean distance: 15.74 (cluster 52) | S | N | B | C | P |
Cross-listing: Chemistry Tree
Parents
Sign in to add mentor| Ronald M. Lechan | grad student | Tufts Medical Center | |
| Richard H. Goodman | post-doc | OHSU |
Children
Sign in to add trainee| James Smart | grad student | 2004 | OHSU |
| Shane T. Hentges | post-doc | OHSU | |
| Marcelo Rubinstein | post-doc | OHSU | |
| Amanda L. Sharpe | post-doc | ||
| Daniel D. Lam | post-doc | 2010-2014 | University of Michigan |
| Aaron Jeffrey Mercer | post-doc | 2011-2015 | University of Michigan |
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Publications
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| Yu H, Chiang A, Rubinstein M, et al. (2024) The homeodomain transcription factor Six3 regulates hypothalamic Pomc expression and its absence from POMC neurons induces hyperphagia and mild obesity in male mice. Molecular Metabolism. 101993 |
| Rojo D, Hael CE, Soria A, et al. (2024) A mammalian tripartite enhancer cluster controls hypothalamic expression, food intake, and body weight. Proceedings of the National Academy of Sciences of the United States of America. 121: e2322692121 |
| Eliason NL, Martin L, Low MJ, et al. (2022) Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food. Neuropeptides. 96: 102289 |
| Yu H, Rubinstein M, Low MJ. (2022) Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes. Elife. 11 |
| Surbhi, Wittmann G, Low MJ, et al. (2021) Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency. Molecular Metabolism. 101312 |
| Shakya M, Gahlot S, White A, et al. (2021) Mice lacking PC1/3 expression in POMC-expressing cells do not develop obesity. Endocrinology |
| Na ES, Lam DD, Yokosawa E, et al. (2020) Decreased sensitivity to the anorectic effects of leptin in mice that lack a Pomc-specific neural enhancer. Plos One. 15: e0244793 |
| Hael CE, Rojo D, Orquera DP, et al. (2020) The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight. Molecular Metabolism. 34: 43-53 |
| Yu H, Thompson Z, Kiran S, et al. (2020) Expression of a hypomorphic Pomc allele alters leptin dynamics during late pregnancy. The Journal of Endocrinology |
| Gahlot S, Wittmann G, Lechan RM, et al. (2020) OR16-03 Metabolic Effects Of Hypothalamic Pomc Neurons Generated Postnatally From Tanycytes On A Pomc Null Genetic Background Journal of the Endocrine Society. 4 |