James T. McLaughlin, Ph.D.
Affiliations: | Ora Clinical | Ora Clinical |
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| Barron SC, McLaughlin JT, See JA, et al. (2009) An allosteric modulator of alpha7 nicotinic receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholine. Molecular Pharmacology. 76: 253-63 |
| McLaughlin JT, Barron SC, See JA, et al. (2009) Conformational changes in alpha 7 acetylcholine receptors underlying allosteric modulation by divalent cations. Bmc Pharmacology. 9: 1 |
| Barron SC, Temple BR, See JA, et al. (2009) Homology models of the alpha7 acetylcholine receptor based upon bacterial receptors: Comparison of experimental and in silico derived data Biochemical Pharmacology. 78: 907-908 |
| McLaughlin JT, Fu J, Rosenberg RL. (2007) Agonist-driven conformational changes in the inner beta-sheet of alpha7 nicotinic receptors. Molecular Pharmacology. 71: 1312-8 |
| McLaughlin JT, Fu J, Sproul AD, et al. (2006) Role of the outer beta-sheet in divalent cation modulation of alpha7 nicotinic receptors. Molecular Pharmacology. 70: 16-22 |
| Lyford LK, Sproul AD, Eddins D, et al. (2003) Agonist-induced conformational changes in the extracellular domain of alpha 7 nicotinic acetylcholine receptors. Molecular Pharmacology. 64: 650-8 |
| Eddins D, Sproul AD, Lyford LK, et al. (2002) Glutamate 172, essential for modulation of L247T alpha7 ACh receptors by Ca2+, lines the extracellular vestibule. American Journal of Physiology. Cell Physiology. 283: C1454-60 |
| Levandoski MM, Lin Y, Moise L, et al. (1999) Chimeric analysis of a neuronal nicotinic acetylcholine receptor reveals amino acids conferring sensitivity to alpha-bungarotoxin. The Journal of Biological Chemistry. 274: 26113-9 |
| Spura A, Russin TS, Freedman ND, et al. (1999) Probing the agonist domain of the nicotinic acetylcholine receptor by cysteine scanning mutagenesis reveals residues in proximity to the alpha-bungarotoxin binding site. Biochemistry. 38: 4912-21 |
| McLaughlin JT, Hawrot E, Yellen G. (1995) Covalent modification of engineered cysteines in the nicotinic acetylcholine receptor agonist-binding domain inhibits receptor activation. The Biochemical Journal. 310: 765-9 |