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William J Lehman

Affiliations: 
Boston University, Boston, MA, United States 
Area:
General Biophysics
Website:
https://www.bumc.bu.edu/busm/profile/william-lehman/
Google:
"William Jeffrey Lehman" OR "William J Lehman"
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Parents

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Lionel Israel Rebhun grad student 1966-1969 Princeton (Neurotree)
 (The structural elements responsible for contraction in the ciliate Spirostomum)
Andrew G. Szent-Györgyi post-doc 1969-1972 Brandeis (Cell Biology Tree)
Richard T. Tregear research scientist 1973-1973 Oxford (Physiology Academic Tree)
Kenneth C. Holmes research scientist 1975-1975 MPI for Medical Research (Computational Biology Tree)

Children

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Deanna Dennault grad student 1992-1993 Franklin Pierce University
Michael S. Rosol grad student 2001 Boston University
Anthony R. Cammarato grad student 2004 Boston University
Alnoor Pirani grad student 2008 Boston University
Jasmine Nirody grad student 2010-2011 UCSF (Neurotree)
Xiaochuan Li post-doc MassMutual Financial Group
Anita Ghosh post-doc 2018- Boston University (Cell & Gene Therapy Tree)
Elumalai Pavadai post-doc 2019- Boston University
Julie Hodgkinson post-doc 1995-1998 Hannover Medical School
Chen Xu post-doc 1995-1998 University Of Massachusetts Med Sch Worcester
D. Bryan Foster post-doc 2001-2003 Johns Hopkins
Kiran Pant post-doc 2004-2006 Northeastern University
Agnieszka Galinska-Rakoczy Collins post-doc 2006-2009 Massachusetts General Hospital & Harvard Medical School
Duncan Sousa post-doc 2007-2011 Johns Hopkins Medical School
Worawit Supamumgmee post-doc 2009-2013 Mahidol University
Marek Orzechowski post-doc 2010-2015 Broad Institute (MIT/Harvard)
Michael Rynkiewicz research scientist 2015- Boston University
Farooq Kiani research scientist 2017-2018 Boston University

Collaborators

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BETA: Related publications

Publications

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Barry ME, Rynkiewicz MJ, Pavadai E, et al. (2024) Glutamate 139 of tropomyosin is critical for cardiac thin filament blocked-state stabilization. Journal of Molecular and Cellular Cardiology
Lehman W, Rynkiewicz MJ. (2023) Troponin-I-induced tropomyosin pivoting defines thin-filament function in relaxed and active muscle. The Journal of General Physiology. 155
Halder SS, Rynkiewicz MJ, Creso JG, et al. (2023) Mechanisms of pathogenicity in the hypertrophic cardiomyopathy-associated TPM1 variant S215L. Pnas Nexus. 2: pgad011
Doran MH, Rynkiewicz MJ, Rassici D, et al. (2023) Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin. The Journal of General Physiology. 155
Doran MH, Rynkiewicz MJ, Pavadai E, et al. (2022) Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation. The Journal of General Physiology. 155
Rynkiewicz MJ, Pavadai E, Lehman W. (2022) Modeling Human Cardiac Thin Filament Structures. Frontiers in Physiology. 13: 932333
Suphamungmee W, Lehman W, Morgan KG. (2022) Functional Remodeling of the Contractile Smooth Muscle Cell Cortex, a Provocative Concept, Supported by Direct Visualization of Cortical Remodeling. Biology. 11
Pavadai E, Rynkiewicz MJ, Yang Z, et al. (2022) Modulation of cardiac thin filament structure by phosphorylated troponin-I analyzed by protein-protein docking and molecular dynamics simulation. Archives of Biochemistry and Biophysics. 725: 109282
Teekakirikul P, Zhu W, Xu X, et al. (2022) Genetic resiliency associated with dominant lethal mutation causing atrial septal defect with high heritability. Cell Reports. Medicine. 3: 100501
Doran MH, Lehman W. (2021) The Central Role of the F-Actin Surface in Myosin Force Generation. Biology. 10
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