April A. Dukes, Ph.D.

Affiliations: 
2007 University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Neuroscience Biology
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Teresa Hastings grad student 2007 University of Pittsburgh
 (The role of dopamine oxidation in dopamine-induced toxicity, initiation of endoplasmic reticulum stress, and potentiation of rotenone-induced toxicity in differentiated PC12 cells.)
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Van Laar VS, Chen J, Zharikov AD, et al. (2020) α-Synuclein amplifies cytoplasmic peroxide flux and oxidative stress provoked by mitochondrial inhibitors in CNS dopaminergic neurons in vivo. Redox Biology. 37: 101695
Dukes AA, Bai Q, Van Laar VS, et al. (2016) Live imaging of mitochondrial dynamics in CNS dopaminergic neurons in vivo demonstrates early reversal of mitochondrial transport following MPP(+) exposure. Neurobiology of Disease
Van Laar VS, Roy N, Liu A, et al. (2015) Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy. Neurobiology of Disease. 74: 180-93
Hauser DN, Dukes AA, Mortimer AD, et al. (2013) Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4. Free Radical Biology & Medicine. 65: 419-27
Hauser DN, Dukes AA, Mortimer AD, et al. (2013) Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4 Free Radical Biology and Medicine. 65: 419-427
Dukes AA, Van Laar VS, Cascio M, et al. (2008) Changes in endoplasmic reticulum stress proteins and aldolase A in cells exposed to dopamine. Journal of Neurochemistry. 106: 333-46
Van Laar VS, Dukes AA, Cascio M, et al. (2008) Proteomic analysis of rat brain mitochondria following exposure to dopamine quinone: implications for Parkinson disease. Neurobiology of Disease. 29: 477-89
Dukes AA, Korwek KM, Hastings TG. (2005) The effect of endogenous dopamine in rotenone-induced toxicity in PC12 cells. Antioxidants & Redox Signaling. 7: 630-8
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