Jennifer M. Laing, Ph.D.
Affiliations: | 2009 | Pharmacology and Experimental Therapeutics | University of Maryland School of Medicine, Baltimore, MD, United States |
Area:
Neuroscience Biology, Virology Biology, Molecular BiologyGoogle:
"Jennifer Laing"Mean distance: 30533.1
Parents
Sign in to add mentor| Laure Aurelian | grad student | 2009 | University of Maryland Medical School | |
| (Broad spectrum neuroprotection by the HSV-2 gene ICP10PK includes multiple targets and crosstalk between neurons and glial cells.) | ||||
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Publications
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| Aurelian L, Laing JM, Lee KS. (2012) H11/HspB8 and Its Herpes Simplex Virus Type 2 Homologue ICP10PK Share Functions That Regulate Cell Life/Death Decisions and Human Disease. Autoimmune Diseases. 2012: 395329 |
| Smith CC, Lee KS, Li B, et al. (2012) Restored expression of the atypical heat shock protein H11/HspB8 inhibits the growth of genetically diverse melanoma tumors through activation of novel TAK1-dependent death pathways. Cell Death & Disease. 3: e371 |
| Laing JM, Smith CC, Aurelian L. (2010) Multi-targeted neuroprotection by the HSV-2 gene ICP10PK includes robust bystander activity through PI3-K/Akt and/or MEK/ERK-dependent neuronal release of vascular endothelial growth factor and fractalkine. Journal of Neurochemistry. 112: 662-76 |
| Colunga AG, Laing JM, Aurelian L. (2010) The HSV-2 mutant DeltaPK induces melanoma oncolysis through nonredundant death programs and associated with autophagy and pyroptosis proteins. Gene Therapy. 17: 315-27 |
| Burnett JW, Laing JM, Aurelian L. (2008) Acute skin eruptions that are positive for herpes simplex virus DNA polymerase in patients with stem cell transplantation: a new manifestation within the erythema multiforme reactive dermatoses. Archives of Dermatology. 144: 902-7 |
| Wales SQ, Laing JM, Chen L, et al. (2008) ICP10PK inhibits calpain-dependent release of apoptosis-inducing factor and programmed cell death in response to the toxin MPP+. Gene Therapy. 15: 1397-409 |
| Laing JM, Aurelian L. (2008) DeltaRR vaccination protects from KA-induced seizures and neuronal loss through ICP10PK-mediated modulation of the neuronal-microglial axis. Genetic Vaccines and Therapy. 6: 1 |
| Laing JM, Golembewski EK, Wales SQ, et al. (2008) Growth-compromised HSV-2 vector Delta RR protects from N-methyl-D-aspartate-induced neuronal degeneration through redundant activation of the MEK/ERK and PI3-K/Akt survival pathways, either one of which overrides apoptotic cascades. Journal of Neuroscience Research. 86: 378-91 |
| Laing JM, Gober MD, Golembewski EK, et al. (2007) Corrigendum to "Intranasal Administration of the Growth-compromised HSV-2 Vector ΔRR Prevents Kainate-induced Seizures and Neuronal Loss in Rats and Mice". Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1734 |
| Wales SQ, Li B, Laing JM, et al. (2007) The herpes simplex virus type 2 gene ICP10PK protects from apoptosis caused by nerve growth factor deprivation through inhibition of caspase-3 activation and XIAP up-regulation. Journal of Neurochemistry. 103: 365-79 |