Harold T. Orr, Ph.D.
Affiliations: | Institute of Human Genetics | University of Minnesota, Twin Cities, Minneapolis, MN |
Area:
Neurodegenerative disordersGoogle:
"Harold Orr"Mean distance: 106866 (cluster 11)
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Publications
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| Gehrking KM, Andresen JM, Duvick L, et al. (2011) Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model. Human Molecular Genetics. 20: 2204-12 |
| Lam YC, Bowman AB, Jafar-Nejad P, et al. (2006) ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology. Cell. 127: 1335-47 |
| Tsuda H, Jafar-Nejad H, Patel AJ, et al. (2005) The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell. 122: 633-44 |
| Riley BE, Xu Y, Zoghbi HY, et al. (2004) The effects of the polyglutamine repeat protein ataxin-1 on the UbL-UBA protein A1Up. The Journal of Biological Chemistry. 279: 42290-301 |
| Watase K, Weeber EJ, Xu B, et al. (2002) A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration. Neuron. 34: 905-19 |
| Skinner PJ, Vierra-Green CA, Emamian E, et al. (2002) Amino acids in a region of ataxin-1 outside of the polyglutamine tract influence the course of disease in SCA1 transgenic mice. Neuromolecular Medicine. 1: 33-42 |
| Cummings CJ, Sun Y, Opal P, et al. (2001) Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice. Human Molecular Genetics. 10: 1511-8 |
| Fernandez-Funez P, Nino-Rosales ML, de Gouyon B, et al. (2000) Identification of genes that modify ataxin-1-induced neurodegeneration. Nature. 408: 101-6 |
| Davidson JD, Riley B, Burright EN, et al. (2000) Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein. Human Molecular Genetics. 9: 2305-12 |
| Clark HB, Orr HT. (2000) Spinocerebellar ataxia type 1--modeling the pathogenesis of a polyglutamine neurodegenerative disorder in transgenic mice. Journal of Neuropathology and Experimental Neurology. 59: 265-70 |