Tom N. Grammatopoulos, Ph.D.

Affiliations: 
2002 University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
Area:
Cell Biology, Neuroscience Biology
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Parents

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James A. Weyhenmeyer grad student 2002 UIUC
 (Angiotensin's role in hypoxic injury.)
David G. Standaert post-doc 2004-2006 Harvard Medical School
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Publications

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Grammatopoulos TN, Jones SM, Yoshimura M, et al. (2010) Neurotransplantation of stem cells genetically modified to express human dopamine transporter reduces alcohol consumption. Stem Cell Research & Therapy. 1: 36
Liu Z, Meray RK, Grammatopoulos TN, et al. (2009) Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 106: 4635-40
Ahmadi FA, Grammatopoulos TN, Poczobutt AM, et al. (2008) Dopamine selectively sensitizes dopaminergic neurons to rotenone-induced apoptosis. Neurochemical Research. 33: 886-901
Grammatopoulos TN, Outeiro TF, Hyman BT, et al. (2007) Angiotensin II protects against alpha-synuclein toxicity and reduces protein aggregation in vitro. Biochemical and Biophysical Research Communications. 363: 846-51
Outeiro TF, Grammatopoulos TN, Altmann S, et al. (2007) Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models. Biochemical and Biophysical Research Communications. 357: 596-602
St Martin JL, Klucken J, Outeiro TF, et al. (2007) Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra. Journal of Neurochemistry. 100: 1449-57
Grammatopoulos TN, Jones SM, Ahmadi FA, et al. (2007) Angiotensin type 1 receptor antagonist losartan, reduces MPTP-induced degeneration of dopaminergic neurons in substantia nigra. Molecular Neurodegeneration. 2: 1
Grammatopoulos TN, Ahmadi F, Jones SM, et al. (2005) Angiotensin II protects cultured midbrain dopaminergic neurons against rotenone-induced cell death. Brain Research. 1045: 64-71
Grammatopoulos TN, Johnson V, Moore SA, et al. (2004) Angiotensin type 2 receptor neuroprotection against chemical hypoxia is dependent on the delayed rectifier K+ channel, Na+/Ca2+ exchanger and Na+/K+ ATPase in primary cortical cultures. Neuroscience Research. 50: 299-306
Miranda M, Sorkina T, Grammatopoulos TN, et al. (2004) Multiple molecular determinants in the carboxyl terminus regulate dopamine transporter export from endoplasmic reticulum. The Journal of Biological Chemistry. 279: 30760-70
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