Wilhelmus G.J. Hol
Affiliations: | University of Washington, Seattle, Seattle, WA |
Area:
protein crystallography for structure-based design of drugs for tropical diseasesWebsite:
http://knaw.nl/nl/leden/leden/4269Google:
"Wim G.J. Hol"Bio:
http://www.bmsc.washington.edu/WimHol/
http://hoogleraren.ub.rug.nl/?page=showPerson&type=hoogleraar&hoogleraar_id=979
http://alba.ub.rug.nl/promotorum/?page=showPerson&promovendus_id=1832&lang=nl
Mean distance: 10.23 | S | N | B | C | P |
Cross-listing: Crystallography Tree
Parents
Sign in to add mentorJan Drenth | grad student | 1971 | RUG | |
( The three-dimensional structure of subtilisin Novo) |
Children
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Publications
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Devine WG, Díaz González R, Ceballos-Perez G, et al. (2017) From cells, to mice, to target: Characterization of NEU-1053 (SB-443342) and its analogs for treatment of human African trypanosomiasis. Acs Infectious Diseases |
Huang W, Zhang Z, Barros-Álvarez X, et al. (2016) Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors. European Journal of Medicinal Chemistry. 124: 1081-1092 |
Zhang Z, Koh CY, Ranade RM, et al. (2016) 5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors. Acs Infectious Diseases. 2: 399-404 |
Ranade RM, Zhang Z, Gillespie JR, et al. (2015) Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites. Antimicrobial Agents and Chemotherapy. 59: 7128-31 |
Koh CY, Siddaramaiah LK, Ranade RM, et al. (2015) A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens. Acta Crystallographica. Section D, Biological Crystallography. 71: 1684-98 |
Pedró-Rosa L, Buckner FS, Ranade RM, et al. (2015) Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening. Journal of Biomolecular Screening. 20: 122-30 |
Koh CY, Kim JE, Wetzel AB, et al. (2014) Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness. Plos Neglected Tropical Diseases. 8: e2775 |
Zhang Z, Ojo KK, Vidadala R, et al. (2014) Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold. Acs Medicinal Chemistry Letters. 5: 40-44 |
Gadwal S, Korotkov KV, Delarosa JR, et al. (2014) Functional and structural characterization of Vibrio cholerae extracellular serine protease B, VesB. The Journal of Biological Chemistry. 289: 8288-98 |
Koh CY, Nguyen J, Shibata S, et al. (2014) Structure-based drug design against Trypanosoma brucei methionyl-tRNA synthetase Acta Crystallographica Section a Foundations and Advances. 70: C708-C708 |